Is diabetes correlating with small aortic root dimension in general Chinese hypertensive patients?
We read with great interest the recent report from Nardi et al. , suggesting that diabetes was significantly and inversely associated with aortic root dimension (ARD) indexed to BSA in hypertensive patients. The findings of a smaller ARD in diabetic patients were documented in some Western samples [2,3]. Given the limited data regarding this issue and the different effects of race, we tested this relationship in a general population consisting of 5739 Chinese hypertensive participants where descriptions of study design and methodology have been reported elsewhere [4,5].
Conclusions: MetS predicts the risk of T2DM. The quantitative MetS-based prediction model for T2DM risk may improve preventive strategies for T2DM and present considerable public health benefits for the people in mainland China. PMID: 30647739 [PubMed]
A furloughed federal worker who is diabetic said she resorted to rationing her insulin medication because "the thought of having more debt was scarier than the thought of dying" in her sleep.
Independent experts on an FDA advisory panel were equally split when voting on whether to approve an oral treatment for type 1 diabetes developed by Lexicon Pharmaceuticals Inc and France's Sanofi SA.
Authors: Y D, Manjrekar PA, Adhikari P, M C, Ms R Abstract Vitamin D, a steroid hormone is primarily known for its role in calcium and bone mineral homeostasis. Over the years, vitamin D has been implicated in various non-skeletal diseases. The extraskeletal phenomenon can be attributed to the presence of vitamin D receptors (VDRs) in almost all cells and identification of 1-α hydroxylase in extrarenal tissues. The vitamin D deficiency (VDD) pandemic was globally reported with increasing evidence and paralleled the prevalence of diabetes, obesity and cardiovascular diseases (CVDs). A dependent link was propos...
Publication date: Available online 16 January 2019Source: The Lancet Diabetes &EndocrinologyAuthor(s): Maya B Lodish
This study was a retrospective, multicentre, international study in patients carrying the Met918Thr RET variant with no age restrictions. The study was done with registry data from 48 centres globally. Data from patients followed-up from 1970 to 2016 were retrieved from May 1, 2016, to May 31, 2018. Our primary objectives were to determine overall survival, and medullary thyroid carcinoma-specific survival based on whether the patient had undergone early thyroidectomy before the age of 1 year. We also assessed remission of medullary thyroid carcinoma, incidence and treatment of phaeochromocytoma, and the penetrance of extr...
Publication date: Available online 17 January 2019Source: Diabetes &Metabolic Syndrome: Clinical Research &ReviewsAuthor(s): Smadar Cohen Atsmoni, Avivit Brener, Yehudah RothAbstractDiabetes mellitus is the most common endocrine disease, characterized by chronic hyperglycemia. The hyperglycemic milieu leads to endothelial injury in blood vessels of variant size, which results in microangiopathy and macroangiopathy (atherosclerosis). Consequential ischemia of nerves and hyperglycemia by itself lead to nerve degeneration and generalized neuropathy, affecting most often the sensory peripheral nerves and the autonomic ...
ConclusionThere is a decrease in BMR in women with T2DM with postmenopausal osteoporosis. BMR was significantly correlated with level of physical activity and visceral fat.
ConclusionsMore than one-half of the investigated persons had UCG. Controlled HbA1c was associated with lower co-morbidities and higher ES-10Y.
ConclusionOxidative damage, inflammation and autonomic dysregulation may be involved in Telomere/Telomerase dysregulation in diabetes and telomerase levels can be used as a cardio-metabolic marker of diabetes.