Cataract as Early Ocular Complication in Children and Adolescents with Type 1 Diabetes Mellitus.

Cataract as Early Ocular Complication in Children and Adolescents with Type 1 Diabetes Mellitus. Int J Endocrinol. 2018;2018:6763586 Authors: Šimunović M, Paradžik M, Škrabić R, Unić I, Bućan K, Škrabić V Abstract Cataract is a rare manifestation of ocular complication at an early phase of T1DM in the pediatric population. The pathophysiological mechanism of early diabetic cataract has not been fully understood; however, there are many theories about the possible etiology including osmotic damage, polyol pathway, and oxidative stress. The prevalence of early diabetic cataract in the population varies between 0.7 and 3.4% of children and adolescents with T1DM. The occurrence of diabetic cataract in most pediatric patients is the first sign of T1DM or occurs within 6 months of diagnosis of T1DM. Today, there are many experimental therapies for the treatment of diabetic cataract, but cataract surgery continues to be a gold standard in the treatment of diabetic cataract. Since the cataract is the leading cause of visual impairment in patients with T1DM, diabetic cataract requires an initial screening as well as continuous surveillance as a measure of prevention and this should be included in the guidelines of pediatric diabetes societies. PMID: 29755521 [PubMed]
Source: International Journal of Endocrinology - Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Related Links:

Conclusions: NP practice environment affected the quality of care for 2 chronic conditions. Efforts should be implemented to improve NP practice environment to potentially improve care quality.
Source: Medical Care - Category: Health Management Tags: Original Articles Source Type: research
Objective: For patients with gastroparesis, temporary pyloric disruption has been shown to improve symptoms and gastric emptying. Per-oral pyloromyotomy (POP) is an innovative endoscopic procedure to divide the pylorus from within a submucosal tunnel, as a corollary to surgical pyloromyotomy. Here we evaluate subjective and objective outcomes 12-weeks after POP at a high volume center. Methods: The first 100 consecutive patients undergoing POP were included, with procedure dates between January 2016 and October 2017. Patients were evaluated using the Gastroparesis Cardinal Symptom Index (GCSI), and 4-hour solid-phase ...
Source: Annals of Surgery - Category: Surgery Tags: Papers of the 138Th ASA Annual Meeting Source Type: research
Conclusions: The cecal microbiome appears to be important in maintaining immune homeostasis and normal immune responses.
Source: Annals of Surgery - Category: Surgery Tags: Papers of the 138Th ASA Annual Meeting Source Type: research
Typical food store in Brazzaville, Congo. Credit: WHOBy Adelheid Onyango and Bibi GiyoseBRAZZAVILLE, Congo, Aug 14 2018 (IPS)When faced with a crisis, our natural reaction is to deal with its immediate threats. Ateka* came to the make-shift clinic with profuse diarrhoea: they diagnosed cholera. The urgent concern in the midst of that humanitarian crisis was to treat the infection and send her home as quickly as possible. But she came back to the treatment centre a few days later – not for cholera, but because she was suffering from severe acute malnutrition. Doctors had saved her life but not restored her health. And...
Source: IPS Inter Press Service - Health - Category: International Medicine & Public Health Authors: Tags: Africa Development & Aid Environment Food & Agriculture Headlines Health Humanitarian Emergencies Population Poverty & SDGs Source Type: news
Publication date: Available online 13 August 2018Source: The Lancet Diabetes &EndocrinologyAuthor(s): Antonio Ceriello, Louis Monnier, David OwensSummaryGlycaemic variability is an integral component of glucose homoeostasis. Although it has not yet been definitively confirmed as an independent risk factor for diabetes complications, glycaemic variability can represent the presence of excess glycaemic excursions and, consequently, the risk of hyperglycaemia or hypoglycaemia. Glycaemic variability is currently defined by a large and increasing number of metrics, representing either short-term (within-day and between-day ...
Source: The Lancet Diabetes and Endocrinology - Category: Endocrinology Source Type: research
Conclusion: We identified a synonymous variant affecting the second nucleotide of exon 3 in theAVP gene (c.324G#x3e;A) in a family in which adFNDI segregates. Notably, we showed that this variant causes partial missplicing of pre-mRNA, resulting in accumulation of the variant prohormone in ER. Our study suggests that even a small amount of aberrant mRNA might be sufficient to disturb cellular function, resulting in adFNDI.
Source: Neuroendocrinology - Category: Endocrinology Source Type: research
A 25-year-old man with Type 1 diabetes mellitus experienced rapid visual decline and was scheduled for right cataract surgery. At the time of administering an inferotemporal retrobulbar block, a white discharge appeared spontaneously on the surface of the globe. Superotemporally a cyst was found and its contents were subtotally evacuated. Microscopically, eosinophilic, acellular material with chatter artifact and small vacuoles was detected and initially thought to represent a lens choristoma. This material stained moderately with the periodic acid Schiff method and was focally Congo red positive without apple green birefr...
Source: Ophthalmic Plastic and Reconstructive Surgery - Category: Opthalmology Tags: Case Reports Source Type: research
Publication date: Available online 10 May 2017 Source:Molecular and Cellular Endocrinology Author(s): Lei Du, Meng Hao, Chengcheng Li, Wenya Wu, Wenwen Wang, Zhongxuan Ma, Tingting Yang, Nan Zhang, Adelusi Temitope Isaac, Xia Zhu, Ying Sun, Qian Lu, Xiaoxing Yin Diabetic cataract (DC), an identified life-threatening secondary complication of diabetes mellitus, has proven to be a dilemma because of its multifactorial caused and progression. An increasing number of studies have shown that in addition to the maillard reaction, enhanced polyol pathway, and oxidative insults, epithelial mesenchymal transition (EMT) is related ...
Source: Molecular and Cellular Endocrinology - Category: Endocrinology Source Type: research
Abstract Diabetic corneal alterations, such as delayed epithelial wound healing, edema, recurrent erosions, neuropathy/loss of sensitivity, and tear film changes are frequent but underdiagnosed complications of both type 1 (insulin-dependent) and type 2 (non-insulin-dependent) diabetes mellitus. The disease affects corneal epithelium, corneal nerves, tear film, and to a lesser extent, endothelium, and also conjunctiva. These abnormalities may appear or become exacerbated following trauma, as well as various surgeries including retinal, cataract or refractive. The focus of the review is on mechanisms of diabetic co...
Source: Vision Research - Category: Opthalmology Authors: Tags: Vision Res Source Type: research
Discussion Sudden painless vision loss has a wide differential diagnosis and it is usually caused by ischemia at retinal, ocular or cortical level. No history of methanol ingestion or trauma, normal fundoscopy, normal MRI and rapid return of vision after correction of diabetic ketoacidosis strongly suggests that blindness was related to acidosis. Alcoholic ketoacidosis has been reported to cause transient reversible blindness in other case reports and correction of acidosis lead to reversal of blindness. Other rare causes of reversible blindness include posterior reversible encephalopathy syndrome, brain tumors, anterior i...
Source: Journal of Investigative Medicine - Category: Research Authors: Tags: Pulmonary/Critical Care Source Type: research
More News: Cataract Removal | Cataracts | Children | Diabetes | Diabetes Mellitus | Diabetes Type 1 | Endocrinology | Pediatrics