Hypophyseal Involvement in Immunoglobulin G4-Related Disease: A Retrospective Study from a Single Tertiary Center.

Conclusions. IgG4-RD is a broad disease, and all physicians involved have to be aware of the possibility of pituitary dysfunction. Younger patients should be expected. The histopathological feature of pituitary gland biopsy could be atypical. For patients with a longer history, the combination of GC and immunosuppressive agents is favorable. Early and adequate courses of treatment are crucial for the management of IgG4-RH. With GC and/or immunosuppressant treatment, however, pituitary function or diabetes insipidus did not improve considerably. PMID: 29755523 [PubMed]
Source: International Journal of Endocrinology - Category: Endocrinology Tags: Int J Endocrinol Source Type: research

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Abstract OBJECTIVE Rathke's cleft cysts (RCCs) are benign epithelial lesions of the sellar region typically treated via a transsphenoidal approach with cyst fenestration and drainage. At present, there is limited evidence to guide patient selection for operative treatment. Furthermore, there is minimal literature describing factors contributing to cyst recurrence. METHODS The authors conducted a retrospective analysis of 109 consecutive cases of pathology-confirmed RCCs treated via a transsphenoidal approach at a single center from 1995 to 2016. The majority of cases (86.2%) involved cyst fenestration, drainage, a...
Source: Journal of Neurosurgery - Category: Neurosurgery Authors: Tags: J Neurosurg Source Type: research
AbstractPurposeSystematic review and meta-analysis comparing endoscopic and microscopic transsphenoidal surgery for Cushing ’s disease regarding surgical outcomes (remission, recurrence, and mortality) and complication rates. To stratify the results by tumor size.MethodsNine electronic databases were searched in February 2017 to identify potentially relevant articles. Cohort studies assessing surgical outcomes or complication rates after endoscopic or microscopic transsphenoidal surgery for Cushing ’s disease were eligible. Pooled proportions were reported including 95% confidence intervals.ResultsWe included 9...
Source: Pituitary - Category: Endocrinology Source Type: research
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Source: Pituitary - Category: Endocrinology Source Type: research
Authors: Eshghi A, Klein R, Eshghi N, Kuo PH Abstract A 21-year-old man presented with polyuria and polydipsia and was discovered to have diabetes insipidus due to eosinophilic granuloma of the hypothalamus. 18F FDG-PET/CT for metastatic work-up revealed an intensely FDG avid hypothalamic mass and no other sites of disease. PMID: 29724799 [PubMed - as supplied by publisher]
Source: Journal of Nuclear Medicine Technology - Category: Nuclear Medicine Tags: J Nucl Med Technol Source Type: research
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Granulomatosis with polyangiitis (GPA, formerly Wegener ’s granulomatosis) is a multisystem vasculitis of small- to medium-sized blood vessels. Cranial involvement can result in cranial nerve palsies and, rarel...
Source: BMC Neurology - Category: Neurology Authors: Tags: Case report Source Type: research
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Source: Experimental Animals - Category: Research Tags: Exp Anim Source Type: research
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Source: JAMA Dermatology - Category: Dermatology Source Type: research
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Source: Pituitary - Category: Endocrinology Source Type: research
Authors: Jezierska M, Stefanowicz J, Romanowicz G, Kosiak W, Lange M Abstract Langerhans cell histiocytosis is a rare clonal disease characterized by the proliferation of CD1a-positive immature dendritic cells. The purpose of this article was to present an updated review of recent advances in the pathogenesis, clinical features, imaging and treatment of this disease. The discovery of oncogenic BRAF mutations and the presence of proinflammatory cytokines and chemokines confirmed the unusual characteristics of this disease. Currently, children with organ involvement who do not have a good response to chemotherapy and...
Source: Advances in Dermatology and Allergology - Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research
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