Ribosome protection by antibiotic resistance ATP-binding cassette protein [Biochemistry]

The ribosome is one of the richest targets for antibiotics. Unfortunately, antibiotic resistance is an urgent issue in clinical practice. Several ATP-binding cassette family proteins confer resistance to ribosome-targeting antibiotics through a yet unknown mechanism. Among them, MsrE has been implicated in macrolide resistance. Here, we report the cryo-EM structure...

Source: Proceedings of the National Academy of Sciences - May 15, 2018 Category: Science Authors: Weixin Su, Veerendra Kumar, Yichen Ding, Rya Ero, Aida Serra, Benjamin Sian Teck Lee, Andrew See Weng Wong, Jian Shi, Siu Kwan Sze, Liang Yang, Yong-Gui Gao Tags: Biological Sciences Source Type: research