Takayasu arteritis in childhood: misdiagnoses at disease onset and associated diseases

AbstractJuvenile-Takayasu arteritis (j-TA) is a difficult diagnosis and some patients develop uncommon manifestations and associated diseases that may contribute to the delayed diagnosis. Our aim was to identify the misdiagnoses, the associated diseases and the atypical manifestations observed in a j-TA Brazilian multicentre study. 71 children and adolescents who met the classification criteria for j-TA were included. The misdiagnoses, the associated diseases and the atypical manifestations were evaluated. 19 (26.8%) patients had misdiagnoses. The most common of them was aortic coarctation in six (8.4%) patients, followed by rheumatic fever in five (7.0%) and one patient presented with both former diagnoses. Limb pain (two patients), spondyloarthropathy, juvenile idiopathic arthritis (JIA), spinal arteriovenous malformation, polyarteritis nodosa (PAN) and fever of unknown origin (FUO) were other misdiagnoses. Patients who had misdiagnoses previously to j-TA diagnosis presented a trend to have a longer diagnosis delay. 11 (15.5%) patients had 14 TA-associated diseases, such as pulmonary tuberculosis (5 patients), rheumatic fever (2 patients), spondyloarthropathy, polyarticular JIA, Crohn ’s disease, Prader–Willi disease, diabetes mellitus, Moyamoya and primary immunodeficiency. 7 (9.9%) patients presented 10 atypical manifestations, such as pyoderma gangrenosum, erythema nodosum, myositis, chorea, enthesitis, episcleritis, uveitis, hepatomegaly, splenomegaly and ne...
Source: Rheumatology International - Category: Rheumatology Source Type: research

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Abstract In this paper, we will describe a novel lable-free electrochemiluminescent (ECL) immunosensor for the detection of glutamate decarboxylase antibody (GADA) in which Au nanoparticles (AuNPs) had pre-functionalized the indium tin oxide (ITO) glass to support the sensing interface. The preparation of the basal electrode only need a simple two-step drop coating, a thin polymer of hydrolyzed 3-aminopropyl trimethoxysilane, and the AuNPs gel on the ITO substrate. The AuNPs not only enhanced the ECL signal of luminol, but also acted to immobilize the glutamate decarboxylase (GAD) to build the sensing host. This i...
Source: Talanta - Category: Chemistry Authors: Tags: Talanta Source Type: research
quy X Abstract A method to explore the stability of two anti-inflammatory peptides in human synovial fluid (HSF) has been developed and validated using liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS). The two peptides are BQ123 Cyclo(-D-Trp-D-Asp-L-Pro-D-Val-L-Leu, Mw = 610.7) and R-954 (AcOrn[Oic2, (αMe)Phe5, DβNal7, Ile8]desArg9-bradykinin, Mw = 1194.4). Human synovial fluid samples were analyzed after a protein precipitation step with acetonitrile and dilution with mobile phase. DMSO was used as anti-adsorptive agent. We used an octyl silane column with formic acid (0.1%, v/v) ...
Source: Talanta - Category: Chemistry Authors: Tags: Talanta Source Type: research
The syntheses, characterization, cytotoxicity against tumor cells and anti-Mycobacterium tuberculosis activity assays of PtII/PPh3/N,N-disubstituted-N'-acylthioureas complexes with general formulae [Pt(PPh3)2(L)]PF6, PPh3 = triphenylphosphine; L = N,N-disubstituted-N'-acylthiourea, are here reported. The complexes were characterized by elemental analysis, molar conductivity, infrared (IR), nuclear magnetic resonance (NMR) (1H, 13C{1H} and 31P{1H}) spectroscopy. The 31P{1H} NMR data are consistent with the presence of two PPh3 ligands cis to each other position, and one N,N-disubstituted-N'-acylthiourea coordinated to the m...
Source: Journal of the Brazilian Chemical Society - Category: Chemistry Source Type: research
Authors: Liu TY, Zhu YX, Ke PQ, He M, Liang YC, Yao SZ Abstract Unicornuate uterus is a rare disease characterized with reduced fertility, and ovarian tumor diagnosed during pregnancy is uncommon as well. These two diseases have been reported separately. However, patient suffering from both diseases has never been reported before. The authors herein report a case of a 32-year-old Chinese woman presenting with a unicornuate uterus with no horn, who suffered from acute abdominal pain and intra-abdominal hemorrhage at 26 weeks gestation. Incidentally, a borderline ovarian tumor (BOT) and rupture of uterus were found d...
Source: European Journal of Gynaecological Oncology - Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research
In this study, the authors report the sixth case of primary vaginal ESS in the literature and aim to discuss diagnostic criteria and management protocols in the light of the literature. PMID: 29787018 [PubMed - in process]
Source: European Journal of Gynaecological Oncology - Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research
CONCLUSION: Wound breakdown in vulvar and groin surgery is an infrequent occurrence because of the rarity of full radical excision for vulva cancer and infralevator pelvic exenterative surgery. The present experience with NPWT was favourable. PMID: 29787000 [PubMed - in process]
Source: European Journal of Gynaecological Oncology - Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research
Researchers find inclination to buy sugary drinks reduces with graphic tooth decay warningGraphic health warnings like those on cigarette packets, showing rows of rotten teeth on cans of cola and other sugary drinks, could deter some young adults from buying them, a study has shown.Sugary drinks are blamed for fuelling the obesity epidemic, but in spite of the large quantities of sugar they contain – nine teaspoons in a can of Coca Cola – they do not carry a red traffic-light warning, which is voluntary in the UK. Sugar taxes, like thatrecently introduced in the UK, may reduce sales, but obesity experts believe...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Sugar Obesity Food & drink industry Health Business Society UK news Diabetes Source Type: news
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Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Authors: Munir KM, Davis SN PMID: 29788782 [PubMed - as supplied by publisher]
Source: Expert Opinion on Pharmacotherapy - Category: Drugs & Pharmacology Tags: Expert Opin Pharmacother Source Type: research
Effect of operative local anesthesia on postoperative pain outcomes of inflatable penile prosthesis: prospective comparison of two medications, Published online: 25 May 2018; doi:10.1038/s41443-018-0025-7Effect of operative local anesthesia on postoperative pain outcomes of inflatable penile prosthesis: prospective comparison of two medications
Source: International Journal of Impotence Research - Category: Urology & Nephrology Authors: Source Type: research
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