Takayasu arteritis in childhood: misdiagnoses at disease onset and associated diseases
AbstractJuvenile-Takayasu arteritis (j-TA) is a difficult diagnosis and some patients develop uncommon manifestations and associated diseases that may contribute to the delayed diagnosis. Our aim was to identify the misdiagnoses, the associated diseases and the atypical manifestations observed in a j-TA Brazilian multicentre study. 71 children and adolescents who met the classification criteria for j-TA were included. The misdiagnoses, the associated diseases and the atypical manifestations were evaluated. 19 (26.8%) patients had misdiagnoses. The most common of them was aortic coarctation in six (8.4%) patients, followed by rheumatic fever in five (7.0%) and one patient presented with both former diagnoses. Limb pain (two patients), spondyloarthropathy, juvenile idiopathic arthritis (JIA), spinal arteriovenous malformation, polyarteritis nodosa (PAN) and fever of unknown origin (FUO) were other misdiagnoses. Patients who had misdiagnoses previously to j-TA diagnosis presented a trend to have a longer diagnosis delay. 11 (15.5%) patients had 14 TA-associated diseases, such as pulmonary tuberculosis (5 patients), rheumatic fever (2 patients), spondyloarthropathy, polyarticular JIA, Crohn ’s disease, Prader–Willi disease, diabetes mellitus, Moyamoya and primary immunodeficiency. 7 (9.9%) patients presented 10 atypical manifestations, such as pyoderma gangrenosum, erythema nodosum, myositis, chorea, enthesitis, episcleritis, uveitis, hepatomegaly, splenomegaly and ne...
Conclusions: Diabetes and prediabetes occur frequently in survivors of ICU experiencing stress hyperglycemia. Based on the occurrence rate observed in this cohort, structured screening and intervention programs appear warranted.
Conclusions: Total Sequential Organ Failure Assessment may be used to predict severe maternal outcome in obstetric populations admitted to ICU. The Acute Physiology and Chronic Health Evaluation II may be applied to predict severe maternal outcome in hemorrhagic complications. We do not recommend Acute Physiology and Chronic Health Evaluation IV and Simplified Acute Physiology Score III for the prediction of severe maternal outcome.
Trond Vidar Hansen, Anders Vik, Charles N. Serhan
ConclusionsOur study indicates that the antidiabetic effect of mistletoe is mediated by its insulinotropic action and α-glucosidase inhibitory activity, and the effect is due to viscothionin, one of the major bioactive constituents of mistletoe.Graphical abstract
Authors: Lareyre F, Mialhe C, Bourlon F, Habib Y, Dommerc C, Raffort J Abstract BACKGROUND: Transcatheter aortic valve implantation (TAVI) is an alternative to open surgical aortic valve replacement and the impact of diabetes on vascular outcomes is worth of investigation. The aim of our study was to determine if diabetic patients had distinct pre-operative characteristics compared to non-diabetics and to evaluate the impact of the disease on vascular outcomes. METHODS: Four hundred consecutive patients who underwent TAVI with percutaneous transfemoral access were retrospectively included. Vascular outcomes wer...
Conclusions: The GEPARDa version has proven to be a diagnostic tool with excellent performance so that it can be considered a valid tool for the detection of PsA in Argentinian patients.Dermatology
VITAMIN D is an essential vitamin needed to keep bones, teeth and muscles healthy, and a deficiency can cause problems with these body parts. Vitamin D deficiency can be common in the winter, but how do you know if you are deficient? Lower back pain could be one of the symptoms.
Paula R. Knox de Souza, Sabrina S. Ferreira, Fernanda P. B. Nunes, Felipe B. Casagrande, Fernando H. G. Tessaro, Mariana C. F. Silva, Jos é Walber Miranda Costa Cruz, Elsa M. Mamizuka, Joilson O. Martins
Genetic disorder Haemochromatosis can cause liver failure, diabetes and severe arthritis if untreated.
BLOATED stomach pain is usually brought on by eating foods and drinks which cause trapped wind and excess gas. Fizzy drinks are a common culprit - replace them with this soothing juice to relieve a bloated belly and stomach cramps.