Researchers Discover Deadly New Pig Virus That Could Spread to Humans

(KDKA/CBS Local) – Researchers say they have identified a new pig virus that could be a threat to humans. The virus was found to easily make its way into laboratory-cultured cells of humans and other species, a discovery that raises concerns about potential outbreaks in people. Researchers at The Ohio State University and Utrecht University in the Netherlands collaborated to better understand the new virus identified as porcine deltacoronavirus. Their study appears online in the journal PNAS. Scientists say the virus was first discovered in pigs in China in 2012. It was first detected in the United States in 2014 during a diarrhea outbreak in Ohio pigs and has now since been detected in other countries. Scientists say that the pigs infected experience acute diarrhea and vomiting, and it can be fatal. “We’re very concerned about emerging coronaviruses and worry about the harm they can do to animals and their potential to jump to humans,” said Linda Saif, an investigator in Ohio State’s Food Animal Health Research Program at the Ohio Agricultural Research and Development Center. There have been no human cases documented, but scientists are concerned because of the virus’ similarity to SARS (severe acute respiratory syndrome) and MERS (Middle East respiratory syndrome.) Saif says, for now, the only known infections in species other than pigs have been in a laboratory using cultured cells. In addition to cultured human cells, the virus was...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Health News Local TV talkers Source Type: news

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Young Go The Middle East respiratory syndrome-coronavirus (MERS-CoV), first identified in Saudi Arabia, is an emerging zoonotic pathogen that causes severe acute respiratory illness in humans with a high fatality rate. Since its emergence, MERS-CoV continues to spread to countries outside of the Arabian Peninsula and gives rise to sporadic human infections following the entry of infected individuals to other countries, which can precipitate outbreaks similar to the one that occurred in South Korea in 2015. Current therapeutics against MERS-CoV infection have primarily been adapted from previous drugs used for the trea...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
ConclusionPVP-I 7% gargle/mouthwash showed rapid bactericidal activity and virucidal efficacy in vitro at a concentration of 0.23% PVP-I and may provide a protective oropharyngeal hygiene measure for individuals at high risk of exposure to oral and respiratory pathogens.FundingMundipharma Research GmbH&Co. KG (MRG).
Source: Infectious Diseases and Therapy - Category: Infectious Diseases Source Type: research
Extracorporeal life support (ECLS) has been widely utilized to treat neonatal respiratory failure for two decades. However, its uptake in the case of adult respiratory failure has been slow because of a paucity of quality evidence and a sluggish tempo of ECLS-related technological advances. In recent years, interest in ECLS has been piqued after encouraging results were reported from its use during the 2009 H1N1 influenza pandemic. In a world constantly under threat from another influenza epidemic or deadly novel respiratory infection, e.g., the severe acute respiratory syndrome (SARS) virus, the Middle East respiratory sy...
Source: ASAIO Journal - Category: Medical Devices Tags: Review Article Source Type: research
Publication date: Available online 28 December 2017 Source:Antiviral Research Author(s): Min-Han Lin, David C. Moses, Chih-Hua Hsieh, Shu-Chun Cheng, Yau-Hung Chen, Chiao-Yin Sun, Chi-Yuan Chou Severe acute respiratory syndrome coronavirus (SARS-CoV) emerged in southern China in late 2002 and caused a global outbreak with a fatality rate around 10% in 2003. Ten years later, a second highly pathogenic human CoV, MERS-CoV, emerged in the Middle East and has spread to other countries in Europe, North Africa, North America and Asia. As of November 2017, MERS-CoV had infected at least 2102 people with a fatality rate of about ...
Source: Antiviral Therapy - Category: Virology Source Type: research
Abstract Severe acute respiratory syndrome coronavirus (SARS-CoV) emerged in southern China in late 2002 and caused a global outbreak with a fatality rate around 10% in 2003. Ten years later, a second highly pathogenic human CoV, MERS-CoV, emerged in the Middle East and has spread to other countries in Europe, North Africa, North America and Asia. As of November 2017, MERS-CoV had infected at least 2102 people with a fatality rate of about 35% globally, and hence there is an urgent need to identify antiviral drugs that are active against MERS-CoV. Here we show that a clinically available alcohol-aversive drug, dis...
Source: Antiviral Research - Category: Virology Authors: Tags: Antiviral Res Source Type: research
Extracorporeal life support (ECLS) has been widely utilized to treat neonatal respiratory failure for two decades. However, its uptake in the case of adult respiratory failure has been slow because of a paucity of quality evidence and a sluggish tempo of ECLS-related technological advances. In recent years, interest in ECLS has been piqued after encouraging results were reported from its use during the 2009 H1N1 influenza pandemic. In a world constantly under threat from another influenza epidemic or deadly novel respiratory infection, e.g., the severe acute respiratory syndrome (SARS) virus, the Middle East respiratory sy...
Source: ASAIO Journal - Category: Medical Devices Tags: Review Article Source Type: research
Publication date: Available online 12 December 2017 Source:Antiviral Research Author(s): Renqiang Liu, Jinliang Wang, Yu Shao, Xijun Wang, Huilei Zhang, Lei Shuai, Jinying Ge, Zhiyuan Wen, Zhigao Bu Middle East respiratory syndrome coronavirus (MERS-CoV) has been a highly threatening zoonotic pathogen since its outbreak in 2012. Similar to SARS-CoV, MERS-CoV belongs to the coronavirus family and can induce severe respiratory symptoms in humans, with an average case fatality rate of 35% according to the World Health Organization. Spike (S) protein of MERS-CoV is immunogenic and can induce neutralizing antibodies, thus is a...
Source: Antiviral Therapy - Category: Virology Source Type: research
Abstract Middle East respiratory syndrome coronavirus (MERS-CoV) has been a highly threatening zoonotic pathogen since its outbreak in 2012. Similar to SARS-CoV, MERS-CoV belongs to the coronavirus family and can induce severe respiratory symptoms in humans, with an average case fatality rate of 35% according to the World Health Organization. Spike (S) protein of MERS-CoV is immunogenic and can induce neutralizing antibodies, thus is a potential major target for vaccine development. Here we constructed a chimeric virus based on the vesicular stomatitis virus (VSV) in which the G gene was replaced by MERS-CoV S gen...
Source: Antiviral Research - Category: Virology Authors: Tags: Antiviral Res Source Type: research
AbstractIn recent years, unexpected outbreaks of infectious diseases caused by emerging and re-emerging viruses have become more frequent, which is possibly due to environmental changes. These outbreaks result in the loss of life and economic hardship. Vaccines and therapeutics should be developed for the prevention and treatment of infectious diseases. In this review, we summarize and discuss the latest progress in the development of small-molecule viral inhibitors against highly pathogenic coronaviruses, including severe acute respiratory syndrome coronavirus and Middle East respiratory syndrome coronavirus, Ebola virus,...
Source: Frontiers of Medicine - Category: General Medicine Source Type: research
This article is part of the series “From SARS to MERS: Research on highly pathogenic human coronaviruses” (Hilgenfeld & Peiris, Antiviral Res. 100, 286–295 (2013)).
Source: Antiviral Therapy - Category: Virology Source Type: research
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