Leading cause of female infertility linked to hormone exposure in womb

The leading cause of infertility in women, called polycystic ovary syndrome, could have developed when they were in the womb, according to a study of mice.
Source: Health News - UPI.com - Category: Consumer Health News Source Type: news

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CONCLUSION: Some childhood and pre-pregnancy cardiovascular risk factors are associated with adult subfertility. PMID: 29899387 [PubMed - as supplied by publisher]
Source: Pediatric Research - Category: Pediatrics Authors: Tags: Pediatr Res Source Type: research
ConclusionAnti-M üllerian hormone may reconcile the three diagnostic criteria and allow the PCOS diagnosis in women with mild symptoms. No significant correlation was found between AMH and BMI in PCOS women and controls.
Source: Archives of Gynecology and Obstetrics - Category: OBGYN Source Type: research
Conclusion The TP53 and BRCA1 may constitute an inheritable risk factor for PCOS in South Indian women.
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - Category: OBGYN Source Type: research
Abstract BACKGROUND: Oral progestin has recently been used to prevent premature LH surges in ovarian stimulation, and this progestin-primed ovarian stimulation (PPOS) is effective and safe in patients with different ovarian reserves. The current data are lacking regarding how to individualize the gonadotropin dose and regimen for women with polycystic ovarian syndrome (PCOS). A retrospective cohort trial was performed to evaluate the efficacy of progestin-primed milder stimulation with clomiphene citrate (CC) compared to the standard progestin-primed ovarian stimulation (PPOS) protocol for infertile women with PCO...
Source: Reproductive Biology - Category: Reproduction Medicine Authors: Tags: Reprod Biol Endocrinol Source Type: research
Abstract The purpose of this study was to investigate whether a change in the follicular fluid metabolomics profile due to endometrioma is identifiable. Twelve women with ovarian endometriosis (aged
Source: Systems Biology in Reproductive Medicine - Category: Reproduction Medicine Authors: Tags: Syst Biol Reprod Med Source Type: research
Polycystic Ovary Syndrome (PCOS) is a heterogeneous multifactorial endocrine metabolic disorder. In addition to hyperandrogenism, acne, hirsutism, obesity, oligoanovulation and infertility, insulin resistance is also a common feature in women of PCOS. Tumor suppressor genes (TSGs) perform essential function in the maintenance of genomic stability and regulatory pathways influencing the activity of several replication and transcription factors. The main aim of this study was to investigate the association of Single Nucleotide Polymorphisms of TP53, BRCA1and BRCA2 genes with the susceptibility to PCOS in South Indian women.
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - Category: OBGYN Authors: Tags: Full length article Source Type: research
Conclusion Our study provides the first evidence of the pathophysiologic contribution of the well-known angiostatic protein, PF4, on human reproductive biology. The increase of the intrafollicular PF4 and its anti-permeability effect might affect the formation of FF and folliculogenesis in PCOS.
Source: Journal of the Formosan Medical Association - Category: General Medicine Source Type: research
A common cause of infertility may be due to a hormonal imbalance before birth, researchers say.
Source: BBC News | Health | UK Edition - Category: Consumer Health News Source Type: news
In this study, we investigated the effects of a TTK extract on androgen generation and regulation of steroidogenic enzymes in vitro and in vivo. Human adrenocortical NCI-H295R cells were used to assess the effects of TTK extract on production of dehydroepiandrosterone and testosterone, as well as the protein expression of steroidogenic enzymes. Further, a letrozole-induced PCOS rat model was used in vivo to assess whether dietary administration of TTK extract restores normal hormones and reduces PCOS symptoms. TTK extract significantly inhibited forskolin (FOR)-induced androgen production in NCI-H295R cells and serum lutei...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
Conclusion Findings of this study showed that risk factors of recurrent abortion, TPO-Ab and uterine leiomyoma have significant importance in pregnant patients undergoing ART.
Source: Middle East Fertility Society Journal - Category: Reproduction Medicine Source Type: research
More News: Health | Hormones | Infertility | Ovaries | Polycystic Ovary Syndrome | Reproduction Medicine | Study | Women