Polycystic ovary syndrome: Scientists closer to understanding cause

A common cause of infertility may be due to a hormonal imbalance before birth, researchers say.
Source: BBC News | Health | UK Edition - Category: Consumer Health News Source Type: news

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Conditions:   Infertility;   Polycystic Ovary Syndrome Intervention:   Behavioral: Fasting Sponsor:   Cairo University Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
AbstractPurposeTo evaluate the potential application of a nomogram based on woman ’s age and ovarian reserve markers as a tool to optimize the follicle-stimulating hormone (FSH) starting dose in intrauterine insemination (IUI) cycles.MethodsWe conducted a retrospective analysis enrolling 179 infertile women undergoing controlled ovarian stimulation (COS), followed by IUI. Each woman received an FSH starting dose according to clinical decision. After collecting data about COS and IUI procedures, we calculated the FSH starting dose according to the nomogram. The main outcomes measured were women ’s baseline chara...
Source: Archives of Gynecology and Obstetrics - Category: OBGYN Source Type: research
Vitamin D deficiency in women diagnosed with polycystic ovary syndrome (PCOS) remarkably decreases the chance of pregnancy, which might be related to its impact on metabolic abnormalities in these patients. It...
Source: Reproductive Biology and Endocrinology - Category: Endocrinology Authors: Tags: Research Source Type: research
CONCLUSION: Overall, the findings of this trial supported that 50,000 IU vitamin D supplementation every other week for 8 weeks had beneficial effects on insulin metabolism, and lipid profile of infertile women with PCOS who are candidate for IVF. These benefits might not be evident upon having sufficient vitamin D levels. TRIAL REGISTRATION: This study was retrospectively registered in the Iranian website ( www.irct.ir ) for clinical trials registration ( http://www.irct.ir : IRCT20170513033941N27). PMID: 30286768 [PubMed - in process]
Source: Reproductive Biology - Category: Reproduction Medicine Authors: Tags: Reprod Biol Endocrinol Source Type: research
Polycystic ovary syndrome (PCOS) is a reproductive, endocrine, and metabolic disorder affecting millions of women worldwide. Women with PCOS are often identified in adolescence or early adulthood with symptoms of oligomenorrhea or hirsutism or when presenting for infertility care. The health risks associated out of PCOS, however, go far beyond management of these common presenting symptoms or fertility treatment and likely extend past the reproductive years through and beyond menopause. International surveys suggest that most patients are dissatisfied with long-term counseling related to medical and psychologic issues.
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: Views and reviews Source Type: research
Abstract Telomeres are repeated DNA sequences whose main function is to preserve genome stability, protecting chromosomes ends from shortening caused by progressive loss during each cell replication or DNA damage. Telomere length regulation is normally achieved by telomerase enzyme, whose activity is progressively shut off during embryonic differentiation in somatic tissues, whereas it is maintained in germ cells, activated lymphocytes, and certain types of stem cell populations. The maintenance of telomerase activity for a longer time is necessary for germ cells to delay telomere erosion, avoiding thus chromosome...
Source: Biology of Reproduction - Category: Reproduction Medicine Authors: Tags: Biol Reprod Source Type: research
CONCLUSION: In summary, Th1 and Th17 bias and reduction of Treg and Th2 cells as regulators of immune responses might be involved in the pathogenesis of PCOS. These results are suggestive of an altered immune response to inflammatory status in PCOS patients, likely causing some complications such as infertility in these patients. PMID: 30246693 [PubMed - in process]
Source: Iranian Journal of Immunology - Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research
ConclusionThis study showed that PRL, AMH, Age, SGPT, and history of abortion are affecting factors for distinguishing the phenotypes of PCOS.
Source: Middle East Fertility Society Journal - Category: Reproduction Medicine Source Type: research
Testosterone levels vary depending on a person ’s sex, age, and physical activity levels. Testosterone levels that are too high or too low may cause a range of potential complications including infertility and polycystic ovary syndrome (PCOS). Learn more about testosterone levels here.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Endocrinology Source Type: news
Authors: Wang X, Ding X, Xiao X, Xiong F, Fang R Abstract The aim of the present study was to explore the influence of positive simple thyroid peroxidase antibody (TPO-Ab) on female infertility. Venous blood was collected on an empty stomach from infertile female patients (all of whom were in line with the World Health Organization's diagnostic criteria for infertility) receiving treatments at The Affiliated Wuxi Maternity and Child Health Care Hospital of Nanjing Medical University from 2014 to 2017 to detect thyroid function and thyroid antibodies [thyroglobulin antibody (TG-Ab), TPO-Ab and thyroid microsome anti...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
More News: Health | Hormones | Infertility | Ovaries | Polycystic Ovary Syndrome | Reproduction Medicine