Polycystic ovary syndrome: Scientists closer to understanding cause

A common cause of infertility may be due to a hormonal imbalance before birth, researchers say.
Source: BBC News | Health | UK Edition - Category: Consumer Health News Source Type: news

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CONCLUSIONS: Unbalanced production of Cho signal in the follicular fluid may have occurred secondary to membrane damage of cumulus-oocyte-complexes due to CC therapy. PMID: 30024629 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Authors: Anderson RC, Newton CL, Anderson RA, Millar RP Abstract The gonadotropin receptors, luteinising hormone receptor, and follicle-stimulating hormone receptor, play a central role in governing reproductive competency/fertility. Gonadotropin hormone analogues have been utilised clinically for decades, in assisted reproductive therapies, and in the treatment of various infertility disorders. While these treatments are effective, the clinical protocols demand multiple injections, and the hormone preparations can lack uniformity and stability. The past two decades have seen a drive to develop chimeric and modifie...
Source: Endocrine Reviews - Category: Endocrinology Tags: Endocr Rev Source Type: research
Publication date: Available online 17 April 2018Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): Seema PatelAbstractPolycystic ovary syndrome (PCOS) is an endocrine disorder, afflicting females of reproductive age. This syndrome leads to infertility, insulin resistance, obesity, and cardiovascular problems, including a litany of other health issues. PCOS is a polygenic, polyfactorial, systemic, inflammatory, dysregulated steroid state, autoimmune disease, manifesting largely due to lifestyle errors. The advent of biochemical tests and ultrasound scanning has enabled the detection of PCOS in the a...
Source: The Journal of Steroid Biochemistry and Molecular Biology - Category: Biochemistry Source Type: research
ConclusionsThe processes related to the differentially expressed proteins play important roles in fecundity and fecundability. The present study may reveal the cause of various endometrial aberrations as a limiting factor for achieving pregnancy in PCOS women.
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research
ConclusionAccording to these results, although PCOS may have negative effects in different aspects of suffering people, it cannot singly reduce social support and marital satisfaction among infertile women; and infertility can be more important than PCOS for infertile women.
Source: Middle East Fertility Society Journal - Category: Reproduction Medicine Source Type: research
ConclusionThere was a weak, positive relationship between personality type and cortisol in polycystic ovarian syndrome, and the cortisol level was found to be higher in neurotically inclined and psychotically inclined personalities than in normal personalities with PCOS.
Source: Middle East Fertility Society Journal - Category: Reproduction Medicine Source Type: research
Publication date: Available online 6 January 2018Source: Middle East Fertility Society JournalAuthor(s): Kamal M. Zahran, Waleed A. Mostafa, Ahmed M. Abbas, Mansour A. Khalifa, Gamal H. SayedAbstractObjectiveTo compare the effect of adjunctive use of cabergoline with clomiphene citrate (CC) in infertile polycystic ovarian syndrome (PCOS) patients with normal prolactin level.Study designA randomized clinical trial (NCT 02644304).SettingAssiut University Hospital, Assiut, Egypt.Materials and methodsInfertile euprolactinemic PCOS patient were recruited and randomized in a 1:1 ratio to CC plus cabergoline or CC alone. All pati...
Source: Middle East Fertility Society Journal - Category: Reproduction Medicine Source Type: research
ConclusionThe findings show decreased serum Se and Zn levels in the PCOS patients as compared to the controls. Additionally, the results confirm the correlation between zinc and insulin resistance.
Source: Middle East Fertility Society Journal - Category: Reproduction Medicine Source Type: research
ConclusionThis study showed that the pregnancy rate achieved with letrozole/estradiol valerate combination was significantly higher than with letrozole alone. This was attributed to the improvement of endometrial thickness by estradiol valerate.
Source: Middle East Fertility Society Journal - Category: Reproduction Medicine Source Type: research
ConclusionFindings of this study showed that risk factors of recurrent abortion, TPO-Ab and uterine leiomyoma have significant importance in pregnant patients undergoing ART.
Source: Middle East Fertility Society Journal - Category: Reproduction Medicine Source Type: research
More News: Health | Hormones | Infertility | Ovaries | Polycystic Ovary Syndrome | Reproduction Medicine