Polycystic ovary syndrome: Scientists closer to understanding cause
A common cause of infertility may be due to a hormonal imbalance before birth, researchers say.
Conclusion Our study provides the first evidence of the pathophysiologic contribution of the well-known angiostatic protein, PF4, on human reproductive biology. The increase of the intrafollicular PF4 and its anti-permeability effect might affect the formation of FF and folliculogenesis in PCOS.
The leading cause of infertility in women, called polycystic ovary syndrome, could have developed when they were in the womb, according to a study of mice.
In this study, we investigated the effects of a TTK extract on androgen generation and regulation of steroidogenic enzymes in vitro and in vivo. Human adrenocortical NCI-H295R cells were used to assess the effects of TTK extract on production of dehydroepiandrosterone and testosterone, as well as the protein expression of steroidogenic enzymes. Further, a letrozole-induced PCOS rat model was used in vivo to assess whether dietary administration of TTK extract restores normal hormones and reduces PCOS symptoms. TTK extract significantly inhibited forskolin (FOR)-induced androgen production in NCI-H295R cells and serum lutei...
Conclusion Findings of this study showed that risk factors of recurrent abortion, TPO-Ab and uterine leiomyoma have significant importance in pregnant patients undergoing ART.
Conclusion: The study highlights that serum proteins are differentially expressed in PCOS patients and healthy women, and EREG and inhibin βA levels are upregulated by progesterone, which are correlated with ovarian functions. The study suggests that EREG and inhibin βA may be applied as novel potential biomarkers for PCOS with low progesterone level.Cell Physiol Biochem 2018;46:2297 –2310
ConclusionsThe route of progesterone administration, previous OHSS risk and history of PCOS seem to be putative risk factors for GDM in women conceived by ART.
(MedPage Today) -- News and commentary from the endocrinology world
CONCLUSIONS: Preconception intervention with low-dose liraglutide added to metformin is superior to metformin alone in increasing PRs per ET and cumulative PRs in infertile obese women with PCOS, despite comparable weight reduction in both groups. A potential direct crosstalk between GLP-1 and reproductive system needs further exploration. PMID: 29703793 [PubMed - as supplied by publisher]
BOSTON (CBS) – Researchers from the University of Oregon studied six women with polycystic ovary syndrome (PCOS) and found that when they soaked in a hot tub for one hour three to four times a week they experienced a variety of health benefits. After two months, the women had reduced resistance to insulin, lower blood pressure and heart rate and some even had more regular menstrual cycles and clearer skin. PCOS affects about 10% of women of reproductive age. It causes multiple cysts to form on the ovaries and also increases a woman’s risk of obesity, type 2 diabetes, and infertility. The researchers say the hot...
Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in adult women (1). It can't be cured, but thanks to many years of fruitful research and intensive investigation, multiple modalities to help manage the condition throughout a woman's lifetime have emerged. Those of us who have been in practice for more than a decade or two have likely had the experience of managing mothers and daughters with the condition. Many of us have supported our PCOS patients through an adolescence complicated by acne and hair growth, an early adulthood complicated by infertility and irregular menses, and late reproductive age compl...