Baclofen Pump Replacement in a Patient With End-Stage Amyotrophic Lateral Sclerosis: A Case Report Demonstrating Transversus Abdominis Plane Block as the Sole Anesthetic

A patient with end-stage amyotrophic lateral sclerosis (ALS) presented for Baclofen pump replacement. She underwent a left transversus abdominis plane block to anesthetize the left lower quadrant of the abdomen. No sedatives or analgesics were administered, and the procedure was successfully completed without complication. It is prudent to consider anesthetic plans that avoid complications associated with general or neuraxial anesthesia in patients with ALS. This case report demonstrates successful placement of a transversus abdominis plane block in a patient with ALS and offers a safe anesthetic technique that can be performed in other high-risk patients.
Source: A&A Case Reports - Category: Anesthesiology Tags: Case Report Source Type: research

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A 25-year-old woman (G2P1) was diagnosed at 27 weeks-of-gestation with clinically definite amyotrophic lateral sclerosis (ALS), according to the revised El Escorial electrophysiological criteria.1 She was referred to the obstetrician for assessment of her pregnancy and to discuss the implications of ALS and delivery. Her previous pregnancy had been uneventful and she had a spontaneous vaginal delivery. At 28 weeks-of-gestation she was seen in consultation by an obstetrician and anesthesiologist.
Source: International Journal of Obstetric Anesthesia - Category: Anesthesiology Authors: Source Type: research
Conclusions Combined spinal-epidural anaesthesia was a good option as anaesthetic technique for caesarean section in this patient with amyotrophic lateral sclerosis.
Source: Colombian Journal of Anesthesiology - Category: Anesthesiology Source Type: research
Publication date: 26 December 2017 Source:Neuroscience, Volume 367 Author(s): Filippo Ghezzi, Laura Monni, Silvia Corsini, Rossana Rauti, Andrea Nistri In brainstem motor networks, hypoglossal motoneurons (HMs) play the physiological role of driving tongue contraction, an activity critical for inspiration, phonation, chewing and swallowing. HMs are an early target of neurodegenerative diseases like amyotrophic lateral sclerosis that, in its bulbar form, is manifested with initial dysphagia and dysarthria. One important pathogenetic component of this disease is the high level of extracellular glutamate due to uptake block ...
Source: Neuroscience - Category: Neuroscience Source Type: research
Unmasking of latent neurodegenerative disease has been reported following exposure to chemicals that share one or more mechanisms of action in common with those implicated in the specific disease. For example, unmasking of latent Parkinson's disease (PD) has been associated with exposure to anti‐dopaminergic agents, while the progression of pre‐existing mild cognitive impairment and unmasking of latent Alzheimer's disease has been associated with exposure to general anesthetic agents which promote Aβ protein aggregation. This literature review and clinical case report about a 45‐year‐old man with no family his...
Source: American Journal of Industrial Medicine - Category: Occupational Health Authors: Tags: CASE REPORT Source Type: research
Publication date: Available online 16 August 2017 Source:Respiratory Physiology & Neurobiology Author(s): Nicole L. Nichols, Taylor A. Craig, Miles A. Tanner Amyotrophic lateral sclerosis (ALS) is a devastating disease leading to progressive motor neuron degeneration and death by ventilatory failure. In a rat model of ALS (SOD1G93A), phrenic long-term facilitation (pLTF) following acute intermittent hypoxia (AIH) is enhanced greater than expected at disease end-stage but the mechanism is unknown. We suggest that one trigger for this enhancement is motor neuron death itself. Intrapleural injections of cholera toxin B f...
Source: Respiratory Physiology and Neurobiology - Category: Respiratory Medicine Source Type: research
Authors: Gu J, Lin X PMID: 28607339 [PubMed - as supplied by publisher]
Source: Minerva Anestesiologica - Category: Anesthesiology Tags: Minerva Anestesiol Source Type: research
Conclusion: Sugammadex can be used successfully to reverse neuromuscular blockade in patients with motor neuron disease.
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
Publication date: Available online 15 May 2017 Source:Journal of Clinical Neuroscience Author(s): Kazuko Hayashi, Ryuhei Araki, Akiko Tanaka Recently, the cognitive abilities of patients with amyotrophic lateral sclerosis (ALS) have been found to be impaired along with the neurodegeneration of motor neurons. Electroencephalography (EEG) of end-stage ALS patients has reportedly shown specific features based on neuronal network modulations, differing from EEG of other patients with cognitive failure and dementia. However, EEG of end-stage ALS patients during anaesthesia has not yet been reported. A 64-year-old male ALS pati...
Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research
Conclusion—Ketamine may be an alternative treatment for resistant depression and may have a special use in patients with multiple sclerosis. Introduction Depression is a frequent finding in patients with multiple sclerosis (MS), with the lifetime prevalence rates for major depressive disorder (MDD) ranging from 36 to 54 percent, more than twice of that in the general population.[1] Even with advances in pharmacological options for treating depression, an estimated 33 to 66 percent of patients with MDD in the general population do not respond to the first antidepressant, and a reported 15 to 33 percent of patients do ...
Source: Innovations in Clinical Neuroscience - Category: Neuroscience Authors: Tags: Case Report Current Issue Depression Multiple Sclerosis Neurology Psychiatry Psychopharmacology Electroconvulsive therapy Ketamine major depressive disorder treatment-resistant depression Source Type: research
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Source: Cochrane News and Events - Category: Information Technology Authors: Source Type: news
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