Endothelin Signaling Contributes to Modulation of Nociception in Early-stage Tongue Cancer in Rats

Background Patients with early stage tongue cancer do not frequently complain of tongue pain. Endothelin-1 signaling is upregulated in the cancerous tongue at the early stage. We tested the hypothesis that endothelin-1 signaling contributes to the modulation of tongue nociception.Methods Squamous cell carcinoma cells were inoculated into the tongue under general anesthesia. Lingual mechanical sensitivity under light anesthesia using forceps from days 1 to 21 (n = 8) and the amounts of endothelin-1 and β-endorphin in the tongue on days 6, 14, and 21 (n = 5 to 7) were examined after the inoculation. The effect of endothelin-A or µ-opioid receptor antagonism on the mechanical sensitivity was examined (n = 5 to 7).Results Lingual mechanical sensitivity did not change at the early stage (days 5 to 6) but increased at the late stage (days 13 to 14). The amount of endothelin-1 increased (25.4  ± 4.8 pg/mlvs. 15.0  ± 5.2 pg/ml;P = 0.008), and endothelin-A receptor antagonism in the tongue induced mechanical hypersensitivity at the early stage (51  ± 9 gvs. 81  ± 6 g;P = 0.0001). The µ-opioid receptor antagonism enhanced mechanical hypersensitivity (39 ± 7 gvs. 81  ± 6 g;P
Source: Anesthesiology - Category: Anesthesiology Source Type: research

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In this study we aimed to elicit the impact of different palliative therapy options on survival in a nationally representative sample of sinonasal cancer patients.MethodsNational Cancer Database 2004 ‐2015 data sets were queried for cases of primary sinonasal cancer (N = 380). Kaplan‐Meier analysis was utilized to determine median overall survival (M‐OS) and overall survival (OS) among the different treatment cohorts (pain management, palliative radiation therapy, palliative chemotherapy, palliative surgery, and combination therapy). Prognostic factors were elicited by comparing OS by log‐rank tests and subsequent ...
Source: International Forum of Allergy and Rhinology - Category: Allergy & Immunology Authors: Tags: ORIGINAL ARTICLE Source Type: research
Publication date: Available online 27 August 2019Source: Journal of Geriatric OncologyAuthor(s): Terufumi Kawamoto, Naoto Shikama, Masaki Oshima, Yasuo Kosugi, Masahiko Tsurumaru, Keisuke SasaiAbstractObjectivesConsidering that therapeutic strategies for older adult patients with esophageal cancer (EC) remain controversial, we aimed to assess the safety of radiotherapy with concurrent docetaxel (DOC-RT) among older adult patients with EC.Materials and MethodsEligible patients included those aged ≥76 years who were diagnosed with esophageal squamous cell carcinoma. Patients received radiotherapy (60 Gy in 30 fraction...
Source: Journal of Geriatric Oncology - Category: Cancer & Oncology Source Type: research
Background: Nonmelanoma skin cancer (NMSC) includes basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) and are the most common skin cancers in the world. This term also encompasses more rare, but aggressive tumors such as sebaceous carcinoma. Many NMSC are detected and treated in the earlier stages of development, however, if left untreated, NMSC can grow to become large, ulcerating, locally destructive, and malignant tumors that may cause functional impairment, significant pain, and bleed frequently.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
We report a case of squamous cell carcinoma secondary to plantar wart in a 72-year-old Chinese woman. 20 years previously the patient found a 1-cm round grayish yellow plaque on her right heel. The lesion was diagnosed as plantar wart by every dermatologist the patient consulted, and can be gradually subsided after treatment such as cryotherapy and photodynamic therapy, but recurred frequently. 2 years previously the plaque enlarged accompanying with aggravated pain, biopsy indicated verrucous hyperplasia.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Carcinogenesis and Cancer Genetics Source Type: research
ConclusionsInfrared coagulation is a safe and effective method for ablation of high-grade anal dysplasia that could help prevent anal cancer. Continued surveillance is recommended due to the risk of recurrence.
Source: Techniques in Coloproctology - Category: Surgery Source Type: research
Publication date: Available online 28 June 2019Source: International Journal of Surgery Case ReportsAuthor(s): Adel Elkbuli, Brianna Dowd, Mark McKenney, Dessy BonevaAbstractIntroductionThe occurrence of Neuroendocrine Carcinoma (NEC) of the colon is
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
Authors: Matsubayashi H, Matsui T, Sugiura T, Makuuchi R, Kaneko J, Satoh J, Satoh T, Fujie S, Ishiwatari H, Sasaki K, Ono H Abstract Pancreatobiliary maljunction (PBM) is a rare congenital malformation, often associated with adenocarcinoma. However, PBM accompanying gallbladder carcinosarcoma has rarely been reported. A 72-year-old woman was referred to our hospital, complaining of abdominal pain. Computed tomography showed a polypoid mass in the gallbladder. Endoscopic retrograde cholangiopancreatography showed PBM, and aspirated bile demonstrated elevated levels of pancreatic-type amylase (26,780 U/L) and cancer...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
Abstract Pain is common among patients with head and neck cancer (HNC). However, there are very limited data on chronic pain among HNC patients treated with radiation therapy (XRT). In this retrospective study, we focused on the characteristics of chronic post-XRT pain in such patients. Post-XRT pain is common among HNC patients; however, we found discrepancy between frequency of treatment and frequency of chronic pain, suggesting poor documentation of pain in the medical records. Among patients who reported to have chronic post-XRT pain, most of them described having severe pain and used descriptors of neuropathi...
Source: Pain Research and Management - Category: Anesthesiology Authors: Tags: Pain Res Manag Source Type: research
This study is a prospective, multi-center, open, single-arm clinical trial designed to enroll 27 patients with locally recurrent ESCC after radiotherapy with or without chemotherapy. Re-irradiation will be performed using intensity modulated radiation therapy in 50 Gy/25 fractions. The strategy of PLDR includes dividing 2 Gy into 10 fractions, and administering each irradiating dose of 20 cGy at an interval of 3 minutes before the next low-dose irradiation. The actual dose rate of administration each time will be 16.67 cGy /minute. The primary endpoint in this study is the rate of esophageal perforation. The secondary endp...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Study Protocol Clinical Trial Source Type: research
We report the case of a 74-year-old man who presented with a 1-month history of right chest pain. His left lung was removed 12 years prior. Chest computed tomography (CT) revealed a mass in the right lower lobe. Diagnoses: An excision biopsy of the mass showed lung squamous cell carcinoma. Interventions: We performed radiofrequency ablation. Outcomes: The patient underwent 3.5 and 10 months of follow-up, with a partial response and complete remission, respectively. Lessons: CT-guided radiofrequency ablation is a safe and an effective minimally invasive treatment option. Radiofrequency appears to be a valuable a...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
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