Biologic Impact of Mechanical Power at High and Low Tidal Volumes in Experimental Mild Acute Respiratory Distress Syndrome

Conclusions In experimental mild ARDS, even at low VT, high mechanical power promoted ventilator-induced lung injury. To minimize ventilator-induced lung injury, low VT should be combined with low power.
Source: Anesthesiology - Category: Anesthesiology Source Type: research

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By now most of us are familiar with Brexit, the UK’s pending divorce with the European Union. But in a play on that term, British doctors are also moving towards an exit they’ve dubbed “TRexit” from the most common sort of prostate biopsy: the transrectal ultrasound guided biopsy, or TRUS. Men who test positive on the PSA cancer screening test will usually have a prostate biopsy that’s performed in either of two ways. With a TRUS, doctors guided by an ultrasound machine can sample the prostate using a biopsy needle inserted through the rectum. Alternatively, the biopsy needle can be inserted (...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Diagnosis Prostate Knowledge HPK Source Type: blogs
Publication date: Available online 8 July 2019Source: Carbohydrate PolymersAuthor(s): L.B. Sukhodub, L.F. Sukhodub, M.O. Kumeda, S.V. Prylutska, V. Deineka, Yu. I. Prylutskyy, U. RitterAbstractBioactive composite material in the form of beads, based on natural polysaccharide Chitosan (CS), hydroxyapatite (HA), and C60 fullerene (C60), was synthesized under influence of microwave irradiation (MW). The bead is a 3D matrix consisting of CS macromolecules cross-linked with sodium tripolyphosphate with HA and C60 particles immobilized in its structure. XRD and FTIR data confirmed the formation of calcium deficient carbonate sub...
Source: Carbohydrate Polymers - Category: Biomedical Science Source Type: research
Publication date: Available online 30 May 2019Source: Microbial PathogenesisAuthor(s): Zhifeng Jia, Aqima Wu, Meiling He, Liang Zhang, Chunjie Wang, Aorigele ChenAbstractEscherichia coli (E. coli) O1-induced diarrhea is associated with intestinal microbial imbalance, however, the results of using oral antibiotics still remain poor. To overcome such problem, our study investigates the role of metabolites from stable flies (MSF) in the occurrence of diarrhea. The amino acid composition and molecular weight analysis of MSF by RP-HPLC and GPC, respectively. Besides the normal control group, SPF mice in other group were inocula...
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
Antonella Riccomi1, Giovanni Piccaro2, Dennis Christensen3, Carla Palma1, Peter Andersen3 and Silvia Vendetti1* 1Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy 2Notified Body, Istituto Superiore di Sanità, Rome, Italy 3Department of Infectious Diseases Immunology, Statens Serum Institute, Copenhagen, Denmark Most microbes invading through mucosal surfaces cause disease and therefore strategies to induce mucosal immune responses are strongly needed. Vitamin A metabolites, such as retinoic acid (RA), play crucial roles in programming T and B cells to home to mucosal compa...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
In conclusion, the mouse pharyngeal colonization model is an affordable and accessible experimental system that allows a broader group of research groups to test the importance of their findings in an in vivo model. There is a great deal of overlap between the bacterial and immune factors found to be important in human and murine pharyngeal colonization. Although MHC-II humanized mice could prove useful in answering certain questions, the use of inbred mouse lines appears to be sufficient for evaluation of most questions, both related to bacterial factors and the host immune response. However, when promising treatments or ...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
Conclusions Extracellular vesicles from interferon- γ–primed human umbilical cord mesenchymal stromal cells more effectively attenuatedE. coli–induced lung injury compared with extracellular vesicles from naïve mesenchymal stromal cells, potentiallyvia enhanced macrophage phagocytosis and killing ofE. coli.
Source: Anesthesiology - Category: Anesthesiology Source Type: research
Conclusions In experimental mild acute respiratory distress syndrome, lung damage in the shorter adaptation time group compared with the no adaptation time group was attenuated in a time-dependent fashion by preemptive adaptation of the alveolar epithelial cells and extracellular matrix. Extending the adaptation period increased cumulative power and did not prevent lung damage, because it may have exposed animals to injurious strain earlier and for a longer time, thereby negating any adaptive benefit.
Source: Anesthesiology - Category: Anesthesiology Source Type: research
Conclusion The impact of sepsis on the gut is manifold, e.g., sepsis mediated alteration of the gut-blood barrier and increase in the intestinal permeability, which may correlate with the phenomena of bacterial translocation and lymphatic activation (“toxic-lymph”). Systemic consequences of sepsis are widespread and concern to the coagulative system, the microbiome as well as enzymes, such as pancreatic proteases, MMPs and IAPs. Nevertheless, the therapeutic approaches for modulating the mucosal immune system are still rarely effective in daily routine. Recent published studies showing that treatment with FMT,...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Conclusion: New carbapenem/βLI combinations may be viable alternatives to antimicrobial combination therapy as they displayed high efficacy in vitro and in vivo. Meropenem/Avibactam and Meropenem/Relebactam should be tested on larger sample sizes with different carbapenemases before progressing further in its preclinical development. Introduction Carbapenem resistant Gram-negative bacteria have been gradually increasing in prevalence in recent years. In the United States, the latest CDC Antibiotic Resistance Threat Report indicates that Carbapenem-Resistant Enterobacteriaceae (CREs) are responsible for 9,000 a...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
In this study, we investigated the role of IL-19 in asthmatic animal models in order to determine the therapeutic potential of IL-19-signaling antagonists for treating allergic asthma. Materials and Methods Animals All animal experiments were done using the protocols of the National Institutes of Health standards and guidelines for the care and use of experimental animals. The research procedures were approved by the Animal Ethics Committee of National Cheng Kung University (IACUC NO. 107272 and 105077). Generating IL-20R1 Knockout Mice IL-20R1 knockout(−/−) mice were generated and maintained on a C57BL/6 ...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
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