Thermal proteome profiling of breast cancer cells reveals proteasomal activation by CDK4/6 inhibitor palbociclib

In conclusion, thermal proteome profiling identifies the proteasome and ECM29 protein as mediators of palbociclib activity in breast cancer cells.

Source: EMBO Journal - May 15, 2018 Category: Molecular Biology Authors: Miettinen, T. P., Peltier, J., Härtlova, A., Gierlinski, M., Jansen, V. M., Trost, M., Björklund, M. Tags: Cancer, Molecular Biology of Disease, Post-translational Modifications, Proteolysis & Proteomics Articles Source Type: research