Sleep in amyotrophic lateral sclerosis

Prahlad K Sethi, Nitin K SethiNeurology India 2018 66(3):666-666
Source: Neurology India - Category: Neurology Authors: Source Type: research

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Noninvasive ventilator support using bi-level positive airway pressure/continuous positive airway pressure (BiPAP/CPAP) is commonly utilized for chronic medical conditions like sleep apnea and neuromuscular disorders like amyotrophic lateral sclerosis (ALS) that lead to weakness of respiratory muscles. Generic masks come in standard sizes and are often perceived by patients as being uncomfortable, ill-fitting, and leaky. A significant number of patients are unable to tolerate the masks and eventually stop using their devices. The goal of this project is to develop custom-fit masks to increase comfort, decrease air leakage,...
Source: Journal of Medical Devices, Transactions of the ASME - Category: Medical Devices Source Type: research
Garima Shukla, Anupama GuptaNeurology India 2018 66(3):664-665
Source: Neurology India - Category: Neurology Authors: Source Type: research
Conclusion: This is the first study from India providing insight into the presence of sleep disorders in ALS. About half of the patients of ALS had a poor sleep quality and two-thirds suffered from sleep disturbances.
Source: Neurology India - Category: Neurology Authors: Source Type: research
AbstractBackgroundOn initiation of long-term non-invasive ventilation (NIV), intermittent upper airway obstruction has rarely been described as possibly treatment-induced. Inspiratory pressure effects and the use of an oronasal interface may promote obstructive events in some patients with neuromuscular disease (NMD) and amyotrophic lateral sclerosis (ALS) in particular.MethodsWe evaluated clinical data from 212 patients in whom NIV was initiated using an oronasal mask. Treatment-induced upper airway obstruction (TAO) was defined as an AHI>  5/h along with a relative increase of the AHI in the first treatment nig...
Source: Sleep and Breathing - Category: Respiratory Medicine Source Type: research
Abstract BACKGROUND: On initiation of long-term non-invasive ventilation (NIV), intermittent upper airway obstruction has rarely been described as possibly treatment-induced. Inspiratory pressure effects and the use of an oronasal interface may promote obstructive events in some patients with neuromuscular disease (NMD) and amyotrophic lateral sclerosis (ALS) in particular. METHODS: We evaluated clinical data from 212 patients in whom NIV was initiated using an oronasal mask. Treatment-induced upper airway obstruction (TAO) was defined as an AHI> 5/h along with a relative increase of the AHI in the ...
Source: Sleep and Breathing - Category: Sleep Medicine Authors: Tags: Sleep Breath Source Type: research
Aim: To evaluate the diaphragm dysfunction in patients presenting with Amyotrophic Lateral Sclerosis (ALS)Methods: Demographics, spirometric measurements and arterial blood gasses of ALS patients reffered to our outpatient clinic were recorded. Diaphragm dysfunction was defined as having ≥20% difference in supine and prone FVC, paradoxical abdominal respiration or ≥3% difference in prone or supine SpO2. BIPAP usage, tracheostomy or PEG requirement and mortality rates evaluated.Results: Four hundred fifty one patients were evaluated for diaphragm dysfunction (F/M:198/253, age:58.7±12.3years). Basal FVC (n=318):...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Clinical Problems Others Source Type: research
Discussion: The mouthpiece should alvays be considered for patient with neuromuscular disease that has to start NIV; it is useful to promote a positive approach and a rapid acceptance of the new condition; it should be considered for patients poorly tolerant to NIV or use NIV many hours a day sometimes alternatin with the nasal or fullface mask. In our experience MPV alone or combined with other interfaces improves the quality of patient's life and promotes greater adherence to NIV.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Noninvasive Ventilatory Support Source Type: research
Conclusions: The performance of PSG in ALS allows the evaluation of nocturnal respiratory failure parameters (CT90, AHI, ODI) and its behavior on sleep efficiency, which can serve as early criteria for initiating NIV and therefore help increase survival in these patients.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Noninvasive Ventilatory Support Source Type: research
Introduction: Respiratory insufficiency in amyotrophic lateral sclerosis (ALS)patients is treated by NIMV.Objectives: In select ALS patients we aim to treat respiratory insufficiency via diaphragm pacing.Methods: Between April 2014 and December 2016, we prospectively collected data of 10 ALS patients (6 females, median age 59)who underwent diaphragm pacing and 15 ALS-matched patients who did not. In pacing group, 1 patient had trachestomy, 4 were using BIPAP. In the non-pacing group 1 patient had tracheostomy, 2 were using BIPAP. Patients who were diagnosed to have chronic hypoventilation(FVC
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Clinical Respiratory Physiology, Exercise and Functional Imaging Source Type: research
Introduction: Amyotrophic lateral sclerosis (ALS) is a progressive and fatal neurodegenerative disease characterized primarily by involvement of motor neurons, although involvement of other systems, among which also autonomic nervous system, has been described. The aim of this study was to investigate cardiac autonomic control during sleep in patients with ALS by means of heart rate variability (HRV) analysis.
Source: Sleep Medicine - Category: Sleep Medicine Authors: Tags: Other Source Type: research
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