High time we focus on sleep in amyotrophic lateral sclerosis!

Garima Shukla, Anupama GuptaNeurology India 2018 66(3):664-665
Source: Neurology India - Category: Neurology Authors: Source Type: research

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Silvia Pregnolato1*, Elavazhagan Chakkarapani1, Anthony R. Isles2 and Karen Luyt1 1Department of Neonatal Neurology, Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom 2Behavioural Genetics Group, MRC Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff University, Cardiff, United Kingdom Preterm birth complications are the leading cause of child death worldwide and a top global health priority. Among the survivors, the risk of life-long disabilities is high, including cerebral palsy and impairment of movement, cognition, and behavior. U...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
Conclusions Stroke comprises ischemic stroke and ICH. The immuno-inflammatory process is involved in neural plasticity following events such as a hemorrhage or ischemic stroke. After ischemia, astrocytes, microglia, and MDMs play important roles during rehabilitation with the modulation of cytokines or chemokines, such as TNF-α and IL-1. Moreover, MiRNAs are also important posttranscriptional regulators in these glial mitochondrial responses to cerebral ischemia. ICH involves processes similar and different to those seen in ischemia, including neuronal injury, astrocytic and microglial/macrophage activation, and neu...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Medical marijuana may bring relief to older people who have symptoms like pain, sleep disorders or anxiety due to chronic conditions including amyotrophic lateral sclerosis, Parkinson's disease, neuropathy, spinal cord damage and multiple sclerosis, according to a preliminary study released today that will be presented at the American Academy of Neurology's 71st Annual Meeting in Philadelphia, May 4 to 10, 2019.
Source: World Pharma News - Category: Pharmaceuticals Tags: Featured Research Research and Development Source Type: news
Motor and Nonmotor Symptoms of Parkinson's Disease: Antagonistic Pleiotropy Phenomena Derived from α-Synuclein Evolvability? Parkinsons Dis. 2018;2018:5789424 Authors: Takamatsu Y, Fujita M, Ho GJ, Wada R, Sugama S, Takenouchi T, Waragai M, Masliah E, Hashimoto M Abstract Lewy body diseases, such as Parkinson's disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA), are associated with a wide range of nonmotor symptoms (NMS), including cognitive impairment, depression and anxiety, sleep disorders, gastrointestinal symptoms, and autonomic failure. The reason why such dive...
Source: Parkinsons Disease - Category: Neurology Tags: Parkinsons Dis Source Type: research
Conclusions: Patients with newly diagnosed ALS have poor sleep quality, which is associated with depression and difficulty turning in bed. Longitudinal studies to examine the evolution of sleep quality and the effectiveness of individualized interventions are needed in patients with ALS.
Source: Journal of Clinical Neuromuscular Disease - Category: Neurology Tags: Original Article Source Type: research
Background: No prospective studies compared effects of pressumetric (PCV) and volumetric (ACV) noninvasive ventilation (NIV) on blood gas exchanges and sleep architecture in patients with ALS. We compared overnight effects of these modes of NIV in a population of ALS patients naïve to it.Methods: Seventeen patients were recruited. After a diagnostic polysomnography (PSG), NIV was titrated (Astral 150 Resmed). Then, the patients underwent two PSGs while receiving PCV or ACV in a randomized order. Two patients refused to switch to ACV. In the remaining 15 patients, mean age was 63.4±11.4 yrs, FVC 51.4±24.5 % ...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Noninvasive Ventilatory Support Source Type: research
In conclusion, the appreciation of the efficiency of the cough by the patient rest subjective, its evaluation by the DET in prone position allows of identified by advantage an ineffective cough.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Clinical Problems Source Type: research
Background: Respiratory failure is one of the most common causes of death in ALS patients. Treatment of ALS patients with NIV when FVC
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Noninvasive Ventilatory Support Source Type: research
ConclusionsOur data show that NIV improves hypercapnia ‐associated symptoms within the first 3 months after initiation in spinal as well as bulbar patients, and that beneficial effects are long‐lasting.This article is protected by copyright. All rights reserved.
Source: Acta Neurologica Scandinavica - Category: Neurology Authors: Tags: Original Article Source Type: research
CONCLUSIONS: In ventilated ALS patients, autonomic activations may hardly have a role as surrogates of cortical arousals for assessment of sleep fragmentation and for respiratory scoring. Depression of ANS activity may be related to their poor performance. PMID: 30043387 [PubMed - as supplied by publisher]
Source: Sleep and Breathing - Category: Sleep Medicine Authors: Tags: Sleep Breath Source Type: research
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