A simple and clinically relevant combination of neuroimaging and functional indexes for the identification of those at highest risk of Alzheimer ’s disease

The current challenge in clinical practice is to identify those with mild cognitive impairment (MCI) who are at greater risk of Alzheimer ’s disease (AD) conversion in the near future. The aim of this study was to assess a clinically practical new hippocampal index –hippocampal volume normalized by cerebellar volume (Hippocampus to Cerebellum volume Ratio; HCCR) used alone or in combination with scores on the mini mental state exa mination (MMSE), as a predictor of conversion from MCI to AD. The predictive value of the HCCR was also contrasted to that of the hippocampal volume to intracranial volume (ICV) ratio.
Source: Neurobiology of Aging - Category: Neuroscience Authors: Source Type: research