Age-dependent regulation of excitatory synaptic transmission at hippocampal temporoammonic-CA1 synapses by leptin

The hippocampus is a key target for the hormone leptin and leptin regulation of excitatory synaptic transmission at Schaffer-collateral (SC)-CA1 synapses during ageing are well documented. However, little is known about the age-dependent actions of leptin at the temporoammonic (TA) input to CA1 neurons. Here we show that leptin induces a novel form of NMDA receptor-dependent long term depression (LTD) at adult (12-24 week old) TA-CA1 synapses. Leptin-induced LTD requires activation of canonical JAK2-STAT3 signalling and removal of GluA1-containing AMPA receptors from synapses.
Source: Neurobiology of Aging - Category: Neuroscience Authors: Source Type: research