Evaluation of the clinical application of multiple tumor marker protein chip in the diagnostic of lung cancer
Journal of Clinical Laboratory Analysis, EarlyView.
Publication date: Available online 24 May 2019Source: Innovative Food Science &Emerging TechnologiesAuthor(s): J. Madureira, A. Severino, M. Cojocaru, S. Garofalide, P.M.P. Santos, M.M. Carolino, F.M.A. Margaça, S. Cabo VerdeAbstractThe aim of this study was to evaluate the effects of electron beam treatment on microbiological parameters and bioactive content of cherry tomatoes in order to assess the feasibility of irradiation as a post-harvest treatment for this fruit. E-beam inactivation studies of natural cherry tomatoes microbiota and inoculated potential foodborne pathogens (Salmonella enterica; Escherichia...
Publication date: Available online 24 May 2019Source: Preventive MedicineAuthor(s): Priyanka Gogna, Tasha A. Narain, Dylan E. O'Sullivan, Paul J. Villeneuve, Paul A. Demers, Perry Hystad, Darren R. Brenner, Christine M. Friedenreich, Will D. King, ComPARe Study Group
The purpose of this study was to evaluate the robustness of 3-dimensional conformal technique with MLC position control into the planning target volume (PTV) in stereotactic body radiotherapy for lung cancer. Two techniques using fixed beams were compared; one technique involved setting the MLC position outside the PTV and was referred to as Plan “O.” Another technique involved setting the MLC position inside the PTV and was referred to as Plan “I.” Two tumor motions were simulated: (1) tumor motion on the internal target volume (ITV) boundary and (2) tumor motion on the PTV boundary.
This study aimed to investigate whether the anti-tumor effect of gemcitabine (GEM) in non-small-cell lung cancer (NSCLC) treatment was affected by Danggui Buxue decoction (DBD), and explore the potential mechanisms. The combined use of GEM and DBD showed an enhanced tumor growth inhibition effect in a murine Lewis lung carcinoma (LLC) model. LC-MS/MS results showed that the pharmacokinetic behaviors of a GEM active metabolite, gemcitabine triphosphate (dFdCTP), were found to be altered remarkably in the peripheral blood mononuclear cells (PBMC) of DBD co-administration rats. In addition, after co-administration of DBD with...
The U.S. Food &Drug Administration on Thursday approved Tumor Treating Fields, a therapy involving electric currents that disrupt cancer cell division and inhibit tumor growth, for the first-line treatment of malignant pleural mesothelioma. It is the first treatment in more than 15 years that the FDA approves for mesothelioma. In 2004, the agency added the chemotherapy drug pemetrexed (Alimta) to standard-of-care treatment. The FDA approved Novocure’s NovoTTF-100L System under the agency’s Humanitarian Device Exemption. The approval comes eight months after Novocure, which manufactures and markets the devi...
Analyst, 2019, Advance Article DOI: 10.1039/C9AN00517J, PaperKrissana Khoothiam, Kiatnida Treerattrakoon, Tawin Iempridee, Patraporn Luksirikul, Tararaj Dharakul, Deanpen Japrung MPRCA-GO sensor can detect low amount of miRNAs, which are biomarkers in cancer diagnosis. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
CONCLUSIONS: We have proved that the expression of miRNA-27a-3p, miRNA-31, miRNA-182, and miRNA-195 in patients with LC is different from the expression of these molecules in healthy people. The examination of these microRNAs in plasma could be used in non-invasive lung cancer diagnosis. PMID: 31115013 [PubMed - in process]
CONCLUSIONS: Our findings provide clues regarding the role of HJURP as a tumor promoter in NSCLC via the activation of the Wnt/β-catenin pathway, indicating HJURP may be a promising therapeutic target for NSCLC. PMID: 31115012 [PubMed - in process]
CONCLUSIONS: COX-2 might promote cisplatin resistance in NSCLC by promoting EMT through the AKT signaling pathway activation. PMID: 31115011 [PubMed - in process]
CONCLUSIONS: We demonstrated that linc00261 was lowly expressed in NSCLC tissues and cells. It inhibited cell proliferation and metastasis by downregulating Snail expression via EMT. This might provide a novel sight for the biological treatment for NSCLC. PMID: 31115010 [PubMed - in process]