GSE114428 Genome-wilde expression profiling analysis of yeast cells lacking the decapping activator Scd6

Contributors : Feng He ; Allan JacobsonSeries Type : Expression profiling by high throughput sequencingOrganism : Saccharomyces cerevisiaeTo assess the role of the decapping activator Scd6 in mRNA decay, we used RNA-Seq to analyze the expression profile of yeast cells harboring a deletion of the SCD6 gene. Consistent with our recent model for decapping regulation, we found that Scd6 targets a small number of specific mRNAs in yeast cells. Interestingly, degradation of Scd6-targeted transcripts also requires the functions of the decapping activators Pat1, Lsm1, and Dhh1, suggesting that Scd6 functions together with Pat1, Lsm1, and Dhh1 in promoting mRNA decapping.

Source: GEO: Gene Expression Omnibus - May 15, 2018 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Saccharomyces cerevisiae Source Type: research