Exosomal Cargo Properties, Endothelial Function and Treatment of Obesity Hypoventilation Syndrome: A Proof of Concept Study

Conclusions:Circulating exosomes facilitate important intercellular signals that modify endothelial phenotype, and thus emerge as potential fundamental contributors in the context of OSA/OHS-related endothelial dysfunction. Exosomes may not only provide candidate biomarkers, but are also a likely and plausible mechanism toward OSA/OHS-induced cardiovascular disease.Clinical Trial Registration:Registry: ClinicalTrials.gov, Title: AVAPS-AE Efficacy Study, URL:https://clinicaltrials.gov/ct2/show/NCT01368614, Identifier: NCT01368614Citation:Bhattacharjee R, Khalyfa A, Khalyfa AA, Mokhlesi B, Kheirandish-Gozal L, Almendros I, Peris E, Malhotra A, Gozal D. Exosomal cargo properties, endothelial function and treatment of obesity hypoventilation syndrome: a proof of concept study.J Clin Sleep Med. 2018;14(5):797–807.
Source: Journal of Clinical Sleep Medicine : JCSM - Category: Sleep Medicine Source Type: research