Fibrosis in Ulcerative Colitis and Mucosal Inflammation Fibrosis in Ulcerative Colitis and Mucosal Inflammation
This study investigated ulcerative colitis-associated fibrosis and its possible link to clinical parameters.Alimentary Pharmacology &Therapeutics
Authors: Keyal U, Liu Y, Bhatta AK Abstract Inflammatory bowel disease (IBD) is a chronic relapsing disease of the gastrointestinal tract with unknown etiology and pathogenesis. It includes Crohn's disease (CD) and ulcerative colitis (UC). Approximately one-third of the patients with IBD are seen to develop extraintestinal manifestations, among which cutaneous manifestations are the most common and should be managed in close collaboration with a dermatologist. Depending upon the nature of the association, skin conditions associated with IBD can be listed under 4 categories: specific, reactive, secondary to malnutri...
AbstractInflammatory bowel diseases (IBDs) are associated with a decreased bone mineral density, but the impact on fractures is unknown. In our study, global risk of fracture is increased for patients with IBDs versus controls. This result will help to determine the appropriate assessment with early screening and management of osteoporosis. Inflammatory bowel diseases (IBDs), such as Crohn ’s disease (CD) and ulcerative colitis (UC), are associated with a decreased bone mineral density (BMD). However, the impact on fracture risk is unknown and data are contradictory across studies. In this systematic review and meta-...
Condition: Ulcerative Colitis Interventions: Drug: UTTR1147A; Drug: UTTR1147A Placebo; Drug: Vedolizumab; Drug: Vedolizumab Placebo Sponsor: Genentech, Inc. Recruiting
We aimed to evaluate the association of the patient-reported outcomes for rectal bleeding and stool frequency among patients with ulcerative colitis (UC) in endoscopic remission.
Abstract The enhanced recruitment of leukocytes to the inflamed colon is a key feature of ulcerative colitis (UC). The gut-specific adhesion molecules involved in leukocyte recruitment have emerged as recent therapeutic targets. Nicotine absorbed from smoking has been reported to work protectively in UC patients. Our hypothesis is that nicotine may suppress the aberrant leukocyte recruitment and colonic inflammation via the suppression of the overexpressed gut-specific adhesion molecules in the inflamed colon. To test this hypothesis, the severity of colitis and the degree of leukocyte recruitment induced by gut-s...
CONCLUSION: switching from infliximab RP to CT-P13 is safe and effective at 12 months. The loss of efficacy at 12 months was 15.7%. PMID: 29893581 [PubMed - as supplied by publisher]
Jun Xu, Ning Chen, Zhe Wu, Yang Song, Yifan Zhang, Na Wu, Feng Zhang, Xinhua Ren, Yulan Liu
Discussion The results demonstrate that IL-35-MSCs could ameliorate ulcerative colitis by down-regulating the expression of pro-inflammatory cytokines. Graphical abstract
Colorectal Disease, EarlyView.