Fibrosis in Ulcerative Colitis and Mucosal Inflammation Fibrosis in Ulcerative Colitis and Mucosal Inflammation

This study investigated ulcerative colitis-associated fibrosis and its possible link to clinical parameters.Alimentary Pharmacology &Therapeutics
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news

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Authors: Tsuboi R, Matsumoto S, Miyatani H, Mashima H Abstract An 18-year-old man diagnosed with ileocolonic Crohn's disease with circumferential strictures of the ascending colon started treatment with mesalazine and subsequently underwent right hemicolectomy. After surgery, the patient was started on adalimumab, and the clinical course was favorable. Nine months postoperatively, colonoscopy revealed granular mucosa with circumferential and continuous involvement from the transverse colon down to the rectum, findings which resembled ulcerative colitis. Mesalazine allergy was suspected, and the inflammatory finding...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
Conclusion Rectal LFA lesions frequently progress to typical UC with proximal extension, some of which become intractable to corticosteroid treatment. PMID: 30333412 [PubMed - as supplied by publisher]
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
(Natural News) People suffering from an inflammatory bowel disease (IBD), such as Crohn’s disease and ulcerative colitis, may benefit from common nettle (Urtica dioica). A study published in the Journal of Herbal Medicine suggested that common nettle can improve the quality of life of people with IBD. In the study, researchers from Iran University of...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
Conditions:   Ulcerative Colitis;   Crohn's Disease Intervention:   Sponsor:   Takeda Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Ulcerative Colitis Intervention:   Other: Fecal Microbiota Transplantation Capsules Sponsor:   Alice Højer Christensen Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Ulcerative Colitis;   Crohn's Disease Intervention:   Sponsor:   Takeda Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Ulcerative Colitis Intervention:   Other: Fecal Microbiota Transplantation Capsules Sponsor:   Alice Højer Christensen Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
(Karolinska Institutet) Children who develop inflammatory bowel disease (ulcerative colitis or Crohn's disease) have an increased risk of death, both in childhood and later in life, a study from Karolinska Institutet in Sweden published in the journal Gastroenterology reports. It is therefore important that patients who are diagnosed as children are carefully monitored, argue the researchers behind the study.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Abstract Crohn's disease (CD) is a chronic inflammatory gastrointestinal disorder. Genetic association studies have implicated dysregulated autophagy in CD. Among risk loci identified are a promoter single nucleotide polymorphism (SNP)(rs13361189) and two intragenic SNPs (rs9637876, rs10065172) in immunity-related GTPase family M ( IRGM), a gene that encodes a protein of the autophagy initiation complex. All three SNPs have been proposed to modify IRGM expression, but reports have been divergent and largely derived from cell lines. Here, analyzing RNA-Sequencing data of human tissues from the Genotype-Tissue Expre...
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - Category: Physiology Authors: Tags: Am J Physiol Gastrointest Liver Physiol Source Type: research
We report a unique case of severe new-onset ulcerative colitis in a young male complicated by cytomegalovirus infection who was on ixekizumab therapy for plaque psoriasis. We recommend that clinicians should exercise caution before prescribing ixekizumab as it seems to induce and exacerbate IBD.Case Rep Gastroenterol 2018;12:617 –621
Source: Case Reports in Gastroenterology - Category: Gastroenterology Source Type: research
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