Fibrosis in Ulcerative Colitis and Mucosal Inflammation Fibrosis in Ulcerative Colitis and Mucosal Inflammation
This study investigated ulcerative colitis-associated fibrosis and its possible link to clinical parameters.Alimentary Pharmacology &Therapeutics
Conditions: Ulcerative Colitis Chronic Mild; Ulcerative Colitis Chronic Moderate Interventions: Drug: ABI-M201; Drug: Placebo Sponsors: Assembly Biosciences; Allergan Recruiting
Hannah Witton, 28, from London, has put her stoma bag on show as part of a major new campaign challenging the way the public perceive sufferers of ulcerative colitis and Crohn’s disease.
CONCLUSION: NET-coated microbeads may be commercially developed as a novel tool for automated ANCA screening assays using flow cytometry. PMID: 30994385 [PubMed - in process]
Patients with ulcerative colitis have an increased risk of colorectal cancer. We sought to assess the comparative efficacy of standard white-light endoscopy (SDWLE) or high-definition white-light endoscopy (HDWLE) versus dye-based chromoendoscopy through a meta-analysis and rating the quality of evidence using the GRADE system.
We have read with great interest the recently published article by Pellet et al.1 The authors assessed the efficacy and safety of calcineurin inhibitors as an induction therapy combined with vedolizumab as a maintenance therapy in a cohort of patients with steroid and anti–tumor necrosis factor–refractory ulcerative colitis (UC), using colectomy-free survival as the pr imary end point. Interestingly, this retrospective study identified the female sex, the presence of hemoglobin (Hb) greater than 11.2 g/dL, age, and concomitant immunosuppressant as baseline factors associated with colectomy.
We read with great interest the article by Hanauer et al.1 Their study showed that tofacitinib induction therapy for ulcerative colitis results in a rapid clinical response. We recently used tofacitinib and infliximab as combination rescue therapy to avoid colectomy in a hospitalized patient with severe ulcerative colitis. We also observed a very rap id onset of action.
Condition: Ulcerative Colitis (UC) Interventions: Drug: TD-1473 Dose A; Drug: TD-1473 Dose B; Drug: TD-1473 Dose C Sponsor: Theravance Biopharma Not yet recruiting
In conclusion, our study might provide evidence that GQD treats diarrhea maybe involved in modulating gut microbiota and increasing SCFA levels. Introduction Diarrheal diseases cause approximately 1.7 billion new infections and 0.76 million deaths in children of under 5 years of age annually and are thus the second most common cause of mortality in young children in developing countries (Kotloff et al., 2012, 2013). Outbreaks of such diseases are usually related to infection by common causative agents, mainly rotavirus, Salmonella enterica, and diarrheagenic Escherichia coli (Hodges and Gill, 2010; Kolenda et al., ...
Conclusion Microorganisms are involved in many life activities, and affect their surrounding environment and other organisms. Microorganisms play important roles in human heath, crop growth, livestock farming, environmental management, industrial chemical production and food production. In the 19th century, people first observed microbes using microscopes and began to study them. However, the development of high-throughput sequencing technology has led to generation of large amounts of microbial related data. As a result, machine-learning methods are now being applied to microbiological research. Here, we discuss the curr...
In this study, the gut microbiota of 30 LC patients and 30 healthy controls were examined via next-generation sequencing of 16S rRNA and analyzed for diversity and biomarkers. We found that there was no decrease in significant microbial diversity (alpha diversity) in LC patients compared to controls (P observed = 0.1422), while the composition (beta diversity) differed significantly between patients and controls (phylum [stress = 0.153], class [stress = 0.16], order [stress = 0.146], family [stress = 0.153]). Controls had a higher abundance of the bacterial phylum Actinobacteria and genus Bifidobacterium, while patients wi...