Magnetic particle imaging for radiation-free, sensitive and high-contrast vascular imaging and cell tracking.

Magnetic particle imaging for radiation-free, sensitive and high-contrast vascular imaging and cell tracking.
Curr Opin Chem Biol. 2018 May 10;45:131-138
Authors: Zhou XY, Tay ZW, Chandrasekharan P, Yu EY, Hensley DW, Orendorff R, Jeffris KE, Mai D, Zheng B, Goodwill PW, Conolly SM
Abstract
Magnetic particle imaging (MPI) is an emerging ionizing radiation-free biomedical tracer imaging technique that directly images the intense magnetization of superparamagnetic iron oxide nanoparticles (SPIOs). MPI offers ideal image contrast because MPI shows zero signal from background tissues. Moreover, there is zero attenuation of the signal with depth in tissue, allowing for imaging deep inside the body quantitatively at any location. Recent work has demonstrated the potential of MPI for robust, sensitive vascular imaging and cell tracking with high contrast and dose-limited sensitivity comparable to nuclear medicine. To foster future applications in MPI, this new biomedical imaging field is welcoming researchers with expertise in imaging physics, magnetic nanoparticle synthesis and functionalization, nanoscale physics, and small animal imaging applications.
PMID: 29754007 [PubMed - as supplied by publisher]

Source: Current Opinion in Chemical Biology - May 10, 2018 Category: Biochemistry Authors: Zhou XY, Tay ZW, Chandrasekharan P, Yu EY, Hensley DW, Orendorff R, Jeffris KE, Mai D, Zheng B, Goodwill PW, Conolly SM Tags: Curr Opin Chem Biol Source Type: research