Prevalence and clinicopathological significances of BRAF V600E mutation in Chinese multiple myeloma patients

Based on the study of 205 Chinese patients with multiple myeloma, we demonstrated a prevalence of 9.3% of BRAF V600E mutation, the highest hitherto reported. Additionally, BRAF V600E mutation was found to be associated with hypercalcemia and a male predominance. In subgroup analysis, the BRAF V600E mutation showed prognostic impact on overall survival in younger patients less than 65 years of age. This is the first large scale study revealing the prevalence and clinicopathological significances of BRAF V600E mutation in Chinese myeloma.

Source: Clinical Lymphoma, Myeloma and Leukemia - May 14, 2018 Category: Hematology Authors: Coty H.Y. Cheung, Chi Keung Cheng, Kin-Mang Lau, Rosalina K.L. Ip, Nelson C.N. Chan, Tommy H.C. Tam, Raymond S.M. Wong, Radha Raghupathy, Natalie P.H. Chan, Margaret H.L. Ng Tags: Original Study Source Type: research