Synchronized roles of pannexin and connexin in nasal mucosal epithelia

ConclusionsConnexins participate in the generation of intercellular calcium waves, in which calcium-mediated signaling responses spread to contiguous cells through the gap junction formed by connexins to transmit calcium signaling throughout the airway epithelium. Pannexins in the nasal mucosa may contribute to not only ciliary beat modulation via ATP release, but also regulation of mucus blanket components via H2O efflux. The synchronized roles of pannexin and connexin may provide a new insight into effective mucociliary clearance systems in nasal mucosa.

Source: European Archives of Oto-Rhino-Laryngology - May 14, 2018 Category: ENT & OMF Source Type: research