Saliva Production and Enjoyment of Real-Food Flavors in People with and Without Dysphagia and/or Xerostomia

This study examined palatability and saliva flow associated with dissolvable flavored films. Taste strips with real-food flavors dissolved on the tongues of 21 persons with dysphagia and/or xerostomia and 21 healthy age- and sex-matched adults while sublingual gauze pads absorbed saliva over randomized 3-min trials. Participants rated taste enjoyment for each trial on a hedonic general labeled magnitude scale. Flavored strips elicited more saliva than baseline for both groups, and production was higher for controls than patients (M = 2.386 and 1.091 g, respectively;p  =  0.036). Main effects of flavor were observed for saliva production (p  =  0.002) and hedonics (p  
Source: Dysphagia - Category: Speech-Language Pathology Source Type: research

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Authors: Lugović-Mihić L, Pilipović K, Crnarić I, Šitum M, Duvančić T Abstract Although cheilitis as a term describing lip inflammation has been identified and recognized for a long time, until now there have been no clear recommendations for its work-up and classification. The disease may appear as an isolated condition or as part of certain systemic diseases/conditions (such as anemia due to vitamin B12 or iron deficiency) or local infections (e.g., herpes and oral candidiasis). Cheilitis can also be a symptom of a contact reaction to an irritant or allergen, or may be provoked by sun exposure (actin...
Source: Acta Clinica Croatica - Category: General Medicine Tags: Acta Clin Croat Source Type: research
C. D. van der Rijt Over 90% of patients treated for head and neck cancer with curatively aimed chemo or bioradiotherapy will develop painful mucositis and xerostomia. Sublingually delivered fentanyl (SDL) is a rapid acting opioid to treat breakthrough pain. It is unclear how SDL is absorbed by the mucosa of these patients. Therefore, the aim of this study was to investigate the effects of mucositis and xerostomia on the absorption of SDL. Thirteen patients who received chemo or bioradiotherapy (RT), were given a single dose of fentanyl: Before start of RT, 3 and 6 weeks after start of RT, and 6 weeks after finishing R...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
Publication date: Available online 31 October 2018Source: The Journal of Prosthetic DentistryAuthor(s): Niraja Jaiswal, Pravinkumar G. Patil, Arti Gangurde, Rambhau D. ParkhedkarAbstractStatement of problemThe prosthodontic problems faced by a patient with xerostomia are of great concern. To aid in retention, artificial saliva substitutes should exhibit good wettability on the denture base.PurposeThe purpose of this in vitro study was to evaluate the wettability of 3 different artificial saliva substitutes on heat-polymerized acrylic resin and to compare these properties with natural saliva and distilled water.Materia...
Source: The Journal of Prosthetic Dentistry - Category: Dentistry Source Type: research
We examined quality of life data from two prospective phase 2 studies of de-intensified chemoradiotherapy in patients with HPV-associated oropharyngeal cancer. Overall results were favorable, and most quality of life domains and symptoms returned to baseline by 3 to 6 months. Xerostomia and dysphagia continued to improve beyond 1 year post-treatment.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Source Type: research
The prosthodontic problems faced by a patient with xerostomia are of great concern. To aid in retention, artificial saliva substitutes should exhibit good wettability on the denture base.
Source: Journal of Prosthetic Dentistry - Category: Dentistry Authors: Tags: Research and Education Source Type: research
CONCLUSION: People with parafunction or TMJ symptoms have poorer oral health-related quality of life than those without these symptoms. PMID: 30371683 [PubMed - as supplied by publisher]
Source: Journal of Orofacial Pain - Category: ENT & OMF Tags: J Oral Facial Pain Headache Source Type: research
AbstractTargeted therapies and immunotherapies are associated with a wide range of dermatologic adverse events (dAEs) resulting from common signaling pathways involved in malignant behavior and normal homeostatic functions of the epidermis and dermis. Dermatologic toxicities include damage to the skin, oral mucosa, hair, and nails. Acneiform rash is the most common dAE, observed in 25 –85% of patients treated by epidermal growth factor receptor and mitogen-activated protein kinase kinase inhibitors. BRAF inhibitors mostly induce secondary skin tumors, squamous cell carcinoma and keratoacanthomas, changes in pre-exist...
Source: American Journal of Clinical Dermatology - Category: Dermatology Source Type: research
ConclusionsThe better knowledge of taste and smell alterations according to CT type may provide valuable information for the design of new strategies to tackle CT side effects. It is important to take into account taste and smell dysfunctions and other alterations such as xerostomia together.
Source: Supportive Care in Cancer - Category: Cancer & Oncology Source Type: research
AbstractRestoring esthetics and function for patients with maxillectomy defects presents a complex challenge for the clinician. Obturator prostheses are subject to rotational forces during function, allowing movement into the defect. Gaining prosthesis support from endosseous implants can limit the amount of rotation. Xerostomia and impaired tissue healing caused by radiation therapy further complicates the treatment for such patients. Several resilient and rigid obturator design concepts are available for restoration of such defects. This clinical report describes a design concept used to treat a patient with a maxillecto...
Source: Journal of Prosthodontics - Category: Dentistry Authors: Tags: Original Manuscript Source Type: research
ConclusionsA thorough understanding of the mechanisms involved in salivary gland is necessary in order to design effective therapies for regeneration of damaged salivary glands.
Source: Journal of Oral Biosciences - Category: Biomedical Science Source Type: research
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