Saliva Production and Enjoyment of Real-Food Flavors in People with and Without Dysphagia and/or Xerostomia
This study examined palatability and saliva flow associated with dissolvable flavored films. Taste strips with real-food flavors dissolved on the tongues of 21 persons with dysphagia and/or xerostomia and 21 healthy age- and sex-matched adults while sublingual gauze pads absorbed saliva over randomized 3-min trials. Participants rated taste enjoyment for each trial on a hedonic general labeled magnitude scale. Flavored strips elicited more saliva than baseline for both groups, and production was higher for controls than patients (M = 2.386 and 1.091 g, respectively;p = 0.036). Main effects of flavor were observed for saliva production (p = 0.002) and hedonics (p
Conditions: Xerostomia; Xerostomia Due to Radiotherapy; Xerostomia Due to Hyposecretion of Salivary Gland Intervention: Other: Finger-prick Autologous Blood (FAB) Sponsor: Bedford Hospital NHS Trust Not yet recruiting
Patients with oral squamous cell carcinoma (OSqCCA) frequently require postoperative radiation (PORT), which may include contralateral level IB within the clinical target volume (CTV). The submandibular gland (SMG) is typically included within the level IB CTV; however, the SMG does not contain lymph nodes or lymphatic vessels. We hypothesized that level IB could be adequately irradiated while sparing the SMG to reduce xerostomia. Twelve patients with OSqCCA receiving PORT, which included the contralateral level IB within the planning target volume (PTV), were retrospectively reviewed and replanned using volumetric modulated arc therapy.
ConclusionsED outpatients were found to present a higher incidence of oral-related complications and an inferior oral health status, compared to gender- and age-matched controls. Alterations verified within outpatients were acknowledged to be quite similar to those previously reported within inpatients, in both of nature and severity, thus sustaining that the cranio-maxillofacial region is significantly affected by ED, even in the early/milder forms of the condition, as expectedly verified within outpatients.
Conclusion: Among the tested compositions, saliva substitutes based only on mucin were found to have parameters similar to human whole saliva. Mucin saliva preparations may have wide applicability for patients with e.g. xerostomia or patients using a metal prosthesis.
Effect of dental care on the oral health of Sjögrens syndrome patients. J Biol Regul Homeost Agents. 2018 Mar-Apr;32(2 Suppl. 2):37-43 Authors: Lucchese A, Portelli M, Marcolina M, Nocini PF, Caldara G, Bertossi D, Lucchese C, Tacchino U, Manuelli M Abstract Sjögrens syndrome (SS) is a chronic, systemic autoimmune disease affecting the exocrine glands, particularly the salivary and lacrimal glands. Xerostomia is a major feature of this syndrome and greatly affects patient quality of life. The most typical clinical signs associated with hyposalivation are dysgeusia and dysosmia, dental car...
CONCLUSION: For VMAT of HNC, the fast-rotating O-ring linac at least maintains the plan quality of two arcs on a C-arm linac while reducing the image acquisition and plan delivery time. PMID: 29739713 [PubMed - as supplied by publisher]
Proton therapy plays an important role in the management of head and neck cancer, where the challenging anatomy benefits from dosimetric advantages of protons. The reduction of treatment-related morbidity is significant for oropharyngeal cancer, as increasingly younger, HPV-positive patients with more favorable prognoses are treated. Patient-reported outcome (PRO) instruments such as the MD Anderson Symptom Inventory (MDASI) have described the response profile of symptoms experienced by patients.
ConclusionsThere was a close association between sialadenitis and ONJ in the HNC population. The severity of sialadenitis was positive correlated to ONJ risk. Radiotherapy combined with sialadenitis significantly raised ORN incidence in HNC patients except for NPC patients.Clinical relevanceHNC patients complained that xerostomia from sialadenitis might increase the risk to develop ONJ, especially among those who received radiotherapy.
We sought to evaluate clinical outcomes and toxicities of radiation therapy (RT) alone compared to RT with concurrent chemotherapy (CCT) for nasopharyngeal carcinoma (NPC) treatment. We conducted a retrospective review of consecutive patients with biopsy-proven nonmetastatic NPC who underwent RT at our institution. From May 2001 to April 2015; 62 newly diagnosed NPC patients were treated with three-dimensional conformal radiotherapy (3D-CRT) or intensity-modulated radiotherapy (IMRT) with or without CCT. The patients were classified as follows: 8% stage I, 15% stage II, 32% stage III, and 45% stage IVA/IVB. A total of 76%...