A dual-function fluorescent probe for monitoring the degrees of hypoxia in living cells via the imaging of nitroreductase and adenosine triphosphate.

A dual-function fluorescent probe for monitoring the degrees of hypoxia in living cells via the imaging of nitroreductase and adenosine triphosphate.
Chem Commun (Camb). 2018 May 11;:
Authors: Fang Y, Shi W, Hu Y, Li X, Ma H
Abstract
A new dual-function fluorescent probe is developed for detecting nitroreductase (NTR) and adenosine triphosphate (ATP) with different responses. Imaging application of the probe reveals that intracellular NTR and ATP display an adverse changing trend during a hypoxic process and ATP can serve as a new sign for cell hypoxia.
PMID: 29749411 [PubMed - as supplied by publisher]

Source: Chemical Communications - May 11, 2018 Category: Chemistry Authors: Fang Y, Shi W, Hu Y, Li X, Ma H Tags: Chem Commun (Camb) Source Type: research