Impact of high MIC of fluconazole on outcomes of Candida glabrata bloodstream infection: a retrospective multicenter cohort study

To evaluate the impacts of fluconazole minimum inhibitory concentration (MIC) according to primary antifungal agents on Candida glabrata bloodstream infection (BSI), a multicenter retrospective cohort study was conducted in Korea, concerning the time period from January 2010 to February 2016. A total of 197 adult patients with C. glabrata BSI were included in the study, and neutropenia (P = 0.026), APACHE II score (P = 0.004), and fluconazole resistance (HR 3.960, 95% CI 1.395-11.246, P = 0.010) were associated with 30-day mortality in multivariate analysis.

Source: Diagnostic Microbiology and Infectious Disease - May 12, 2018 Category: Microbiology Authors: Jae-Hoon Ko, Kyong Ran Peck, Dong Sik Jung, Ji Yeon Lee, Hyun Ah Kim, Seong Yeol Ryu, Sook-In Jung, Eun-Jeong Joo, Shinhye Cheon, Yeon-Sook Kim, Shin-Woo Kim, Sun Young Cho, Young Eun Ha, Cheol-In Kang, Doo Ryeon Chung, Nam Yong Lee, Jae-Hoon Song Source Type: research