Convective influx/glymphatic system: tracers injected into the CSF enter and leave the brain along separate periarterial basement membrane pathways

Conclusions drawn from the present study are that tracers injected into the CSF enter and leave the brain along separate periarterial bas ement membrane pathways. The exit route is along IPAD pathways in which Aβ accumulates in cerebral amyloid angiopathy (CAA) in Alzheimer’s disease. Results from this study suggest that CSF may be a suitable route for delivery of therapies for neurological diseases, including CAA.

Source: Acta Neuropathologica - May 12, 2018 Category: Neurology Source Type: research