Association of T and non-T cell Cytokines with Anhedonia: Role of Gender Differences

Several lines of evidence implicate dysfunctional immune response in the pathophysiology of major depressive disorder (MDD) (Miller and Raison, 2016). Over one-third of patients treated with interferon alpha (an inflammatory cytokine) develop significant depressive symptoms (Raison et al., 2005). Depressive symptoms, in turn, are associated with higher levels of non-specific markers of inflammation such as c-reactive protein (CRP) (Cepeda et al., 2016). Patients with MDD have higher levels of inflammatory cytokines such as interleukin (IL)-6 in peripheral circulation and in cerebrospinal fluid as compared to controls (Kern et al., 2014; Kohler et al., 2017).

Source: Psychoneuroendocrinology - May 12, 2018 Category: Psychiatry Authors: Manish K. Jha, Andrew H. Miller, Abu Minhajuddin, Madhukar H. Trivedi Source Type: research