Aberrant Lck signal via CD28 co-stimulation augments antigen-specific functionality and tumor control by redirected T cells with PD-1 blockade in humanized mice.

CONCLUSIONS: Overall, anti-FAP-Δ-CD28/CD3ζ CAR T cells revealed superior in vitro functionality, better tumor control in combination with PD-1 blockade in humanized mice, and persistence up to 21 days in a MPM patient. Therefore, further clinical investigation of this optimized CAR is warranted. PMID: 29748183 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/29748183?dopt=Abstract

Source: Clinical Cancer Research - May 10, 2018 Category: Cancer & Oncology Authors: Gulati P, Rühl J, Kannan A, Pircher M, Schuberth P, Nytko KJ, Pruschy MN, Sulser S, Haefner MD, Jensen SM, Soltermann A, Jungraithmayr W, Eisenring M, Winder T, Samaras P, Tabor A, Stenger RR, Stupp R, Weder W, Renner C, Münz C, Petrausch U Tags: Clin Cancer Res Source Type: research