GSE112178 Molecular characterization of pyrethroid resistance in the olive fruit fly Bactrocera oleae

Contributors : Nena Pavlidi ; Anastasia Kampouraki ; Vasilis Tseliou ; Nicky Wybouw ; Wannes Dermauw ; Emmanouil Roditakis ; Ralf Nauen ; Thomas van Leeuwen ; John VontasSeries Type : Expression profiling by arrayOrganism : Bactrocera oleaeΑ reduction of pyrethroid efficacy has been recently recorded in the olive fruit fly Bactrocera oleae, the most destructive insect pest of olives worldwide.We analyzed the transcriptomic differences between two highly pyrethroid resistant populations versus a relatively susceptible field population and two laboratory strains to gain more insight into the molecular mechanism of resistance.A large number of genes was found to be significantly differentially transcribed across the pairwise comparisons between resistant and susceptible insect populations. Interestingly, gene set analysis revealed that genes of the ‘electron carrier activity’ GO group were enriched in one specific pairwise transcriptomic comparison. As P450 monooxygenase enzymes are typically associated with this Molecular Function GO-group, this might reflect a P450-mediated resistance mechanism.These results suggest that transcriptional induction of the CYP6 P450s might be an important mechanism of pyrethroid resistance in B. oleae and pave the way for the development of synergists and molecular diagnostics for insecticide resistance management.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Bactrocera oleae Source Type: research