Liver regeneration requires Yap1-TGF β-dependent epithelial-mesenchymal transition in hepatocytes

Adult liver has robust regenerative capacity as evidenced by efficient restitution of fully functional liver mass within days-weeks after acute 70% partial hepatectomy (PH) in mice and humans, respectively [1]. Paradoxically, chronically dysregulated repair of even minor liver damage causes defective recovery of healthy liver parenchyma and ultimately results in cirrhosis and/or liver cancer. Preventing these bad outcomes of liver injury is necessary to reduce mortality from liver disease, a major cause of premature death in adulthood worldwide [2].

Source: Journal of Hepatology - May 11, 2018 Category: Gastroenterology Authors: Seh-Hoon Oh, Marzena Swiderska-Syn, Mark L. Jewell, Richard T. Premont, Anna Mae Diehl Source Type: research