Dysbindin-1 contributes to prefrontal cortical dendritic arbor pathology in schizophrenia

This study sought to determine whether MARCKS, its regulatory protein dysbindin-1, and two proteins, identified using microarray data, CDC42BPA and ARHGEF6, were associated with dendritic arbor pathology in the DLPFC from schizophrenia and bipolar disorder subjects. Using western blotting, relative protein expression was assessed in the DLPFC (BA 46) grey matter from subjects with schizophrenia (n  = 19), bipolar disorder (n = 17) and unaffected control subjects (n = 19).
Source: Schizophrenia Research - Category: Psychiatry Authors: Source Type: research