Consequences of Pharmacological BACE Inhibition on Synaptic Structure and Function

Alzheimer ’s disease (AD) is the most prevalent neurodegenerative disorder among the elderly. Overt accumulation and aggregation of the Amyloid β (Aβ) peptide is thought to be the initial causative factor for AD. Aβ is produced by sequential proteolytic cleavage of the amyloid precursor protein. Beta-sit e amyloid precursor protein cleaving enzyme 1 (BACE1) is the initial and rate-limiting protease for the generation of Aβ. Therefore, BACE inhibition is considered as one of the most promising therapeutic approaches for potential treatment of AD.

Source: Biological Psychiatry - May 11, 2018 Category: Psychiatry Authors: Kaichuan Zhu, Finn Peters, Severin Filser, Jochen Herms Tags: Review Source Type: research