Research progress on brucellosis.

Research progress on brucellosis. Curr Med Chem. 2018 May 10;: Authors: Deng Y, Liu X, Duan K, Peng Q Abstract Brucellosis is a debilitating febrile illness caused by an intracellular Brucella. The disease distributed in humans and animals widely, especially in developing countries. Ten species are included in the genus Brucella nowadays; four species of them are pathogenic to humans, which making brucellosis a zoonosis with more than 500,000 new cases reported annually. For human brucellosis, the most pathogenic specie is B. melitensis followed by B. suis, while B. abortus is the mildest type of brucellosis. The infection mechanism of Brucella is complicated and mostly relies on its virulence factors. The therapy of the disease contains vaccination and antibiotic. However, there are some defects in currently available vaccines such as the lower protective level and safety. Thus safe and efficient vaccines for brucellosis are still awaited. The dual therapy of antibacterial is effective in treatment of brucellosis if a rapid and exact detection method is found. PMID: 29745323 [PubMed - as supplied by publisher]
Source: Current Medicinal Chemistry - Category: Chemistry Authors: Tags: Curr Med Chem Source Type: research