UCLA faculty voice: A hangover pill? Tests on drunk mice show promise

UCLAYunfeng LuYunfeng Lu is a professor of chemical and biomolecular engineering in the UCLA Samueli School of Engineerg.  Thiscolumn appeared in the Conversation.“Civilization begins with distillation,” said William Faulkner, a writer and drinker. Although ourthirst for alcohol dates back to the Stone Age, nobody has figured out a good way to deal with the ensuing hangover after getting drunk.As a chemical engineering professor and wine enthusiast, I felt I needed to find a solution. As frivolous as this project may sound, it has serious implications. Between 8 and10 percent of emergency room visits in America are due to acute alcohol poisoning. Alcohol is theleading risk factor for premature deaths and disability among people aged 15-49 and its abuse leads to serious health problems, includingcardiovascular and liver cancer. Despite these sobering facts, current treatments for alcohol overdose largely rely on the body ’s own enzymes to break down this drug.I decided to design an antidote that could help people enjoy wine or cocktails or beer without a hangover, and at the same time create a lifesaving therapy to treat intoxication and overdose victims in the ER. I chose to create capsules filled with natural enzymes usually found in liver cells to help the body process the alcohol faster.Together with professor Cheng Ji, an expert in liver diseases from Keck School of Medicine at the University of Southern California, and my graduate student Duo Xu, w...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news

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Popovici V Abstract The dysfunction of the DNA mismatch repair system results in microsatellite instability (MSI). MSI plays a central role in the development of multiple human cancers. In colon cancer, despite being associated with resistance to 5-fluorouracil treatment, MSI is a favourable prognostic marker. In gastric and endometrial cancers, its prognostic value is not so well established. Nevertheless, recognising the MSI tumours may be important for predicting the therapeutic effect of immune checkpoint inhibitors. Several gene expression signatures were trained on microarray data sets to understand the reg...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
RATIONALE: Carbon monoxide (CO) poisoning can cause severe damage to the nervous system, and can also cause serious damage to organs, such as the heart, kidneys, and lungs. CO damage to myocardial cells has been previously reported. This can lead to seriou...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news
Consuming alcohol mixed with energy drinks (AmED) is a risk behaviour among youth, and previous research has reported a positive association between binge drinking and AmED consumption. However, limited research has examined how regular consumption of ener...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
INTRODUCTION: Substance use disorders (SUD) frequently co-occur with posttraumatic stress disorder (PTSD). Little is known, however, about how individuals with a single SUD diagnosis (relating to only one substance) compare to individuals with poly-SUD dia...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news
Authors: Ravindranath MH, Filippone EJ, Devarajan A, Asgharzadeh S Abstract Cytotoxic NK/CD8+ T cells interact with MHC-I ligands on tumor cells through either activating or inhibiting receptors. One of the inhibitory receptors is CD94/NKG2A. The NK/CD8+ T cell cytotoxic capability is lost when tumor-associated human leukocyte antigen, HLA-E, binds the CD94/NKG2A receptor, resulting in tumor progression and reduced survival. Failure of cancer patients to respond to natural killer (NK) cell therapies could be due to HLA-E overexpression in tumor tissues. Preventing the inhibitory receptor-ligand interaction by eithe...
Source: Monoclonal Antibodies in Immunodiagnosis and Immunotherapy - Category: Microbiology Tags: Monoclon Antib Immunodiagn Immunother Source Type: research
In conclusion, this protein can be used for animal immunization toward preparation of a new monoclonal antibody that can be introduced as a drug in the treatment of breast cancer. PMID: 31009334 [PubMed - in process]
Source: Monoclonal Antibodies in Immunodiagnosis and Immunotherapy - Category: Microbiology Tags: Monoclon Antib Immunodiagn Immunother Source Type: research
Authors: Pencheva-Demireva M, El-Darawish Y, Kavaldzhieva K, Mladenov N, Lazarov V, Dimitrova-Dikanarova D, Markova T, Nikolov R, Okamura H Abstract Natural killer (NK) cells can discriminate between normal and cancer cells and are known to directly recognize and kill malignant cells or induce apoptosis. Thus, activation of NK cells is considered as a promising strategy for cancer treatment. However, clinical application has been somewhat limited because of difficulties in the preparation of sufficient number of highly cytotoxic/activated NK cells in vitro. We used cytokine stimulation to provide a suitable environ...
Source: Monoclonal Antibodies in Immunodiagnosis and Immunotherapy - Category: Microbiology Tags: Monoclon Antib Immunodiagn Immunother Source Type: research
Abstract PROBLEM IDENTIFICATION: The impact of mental health disorders (MHDs) and substance use disorders (SUDs) on healthcare utilization (HCU) in patients with cancer is an understudied phenomenon. LITERATURE SEARCH: A literature search of studies published prior to January 2018 that examined HCU in patients with preexisting MHDs or SUDs diagnosed with cancer was conducted. DATA EVALUATION: The research team evaluated 22 studies for scientific rigor and examined significant trends in HCU, as well as types of the MHD, SUD, and cancer studied. SYNTHESIS: The heterogeneity of HCU outcome measures, MH...
Source: Oncology Nursing Forum - Category: Nursing Authors: Tags: Oncol Nurs Forum Source Type: research
This study provides insight into the experiences of young women living with advanced breast cancer. Because these women may not appear ill to the general population, their needs and struggles are not well understood. The results of this study can be a baseline for additional research and clinical interventions. PMID: 31007263 [PubMed - in process]
Source: Oncology Nursing Forum - Category: Nursing Authors: Tags: Oncol Nurs Forum Source Type: research
Abstract PROBLEM IDENTIFICATION: To evaluate the effects of breathing exercises on dyspnea, six-minute walk distance (6MWD), anxiety, and depression in patients with lung cancer. LITERATURE SEARCH: A systematic literature search of the Cochrane Library, Web of Science, Embase®, PubMed®, Weipu, Wanfang, and Chinese National Knowledge Infrastructure databases was performed for publications dated prior to April 6, 2018. DATA EVALUATION: The meta-analysis was performed using Review Manager and Stata. SYNTHESIS: 15 randomized controlled trials with a total of 870 participants met the inclusion cr...
Source: Oncology Nursing Forum - Category: Nursing Authors: Tags: Oncol Nurs Forum Source Type: research
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