Stimulants and Mood Disorders

AbstractPurposeTo review the epidemiology, diagnosis, and treatment of co-occurring mood disorders (bipolar disorder and major depression) and stimulant use disorders (SUD), which includes cocaine and methamphetamine use disorders.Recent FindingsEpidemiological studies support frequent co-occurrence between mood and SUD. Multiple studies support a bidirectional negative impact between mood and SUD for clinical outcomes and treatment response. Only a few clinical trials were conducted in individuals with mood and SUD comorbidity. The majority of trials for mood disorders have excluded patients with comorbid substance use disorders.SummaryFuture clinical trials that are focused on behavioral and pharmacological treatment of mood and SUD are needed. Further, research focused on understanding the neurobiological mechanisms of mood and SUD comorbidity as well as improving the diagnosis and engagement of these patients is needed.
Source: Current Addiction Reports - Category: Addiction Source Type: research