Relationship between high sodium and low PUFA intake and carotid atherosclerosis in elderly women.

Relationship between high sodium and low PUFA intake and carotid atherosclerosis in elderly women. Exp Gerontol. 2018 May 07;: Authors: Mazza E, Ferro Y, Lamprinoudi T, Gazzaruso C, Doldo P, Pujia A, Montalcini T Abstract Several biologically active molecules including nutrients can affect the vascular endothelium which becomes dysfunctional and, as a consequence, predisposes to atherosclerosis. However, the impact of the intake of sodium and polyunsaturated fatty acids on carotid atherosclerosis in a population of elderly women has scarcely been studied. Our aim was to investigate the association between carotid intima-media thickness and atherosclerotic plaque and nutrient intake in asymptomatic elderly women. Carotid atherosclerosis was determined by duplex ultrasound in 108 elderly women. Dietary intake was assessed by a combination of a 24-hour recall and a 7-day food record. A physical examination and laboratory tests were performed. We found an association between the C-IMT and polyunsaturated fatty acid (negative, B = -0.014; p = 0.03; CI -0.027/-0.001) and sodium (positive, r = 0.16; P = 0.09) intake. When linoleic acid was added to the multivariable regression analysis instead of polyunsaturated fatty acids, C-IMT was associated with linoleic acid (B = -0.017; p = 0.02; CI -0.032/-0.003). In normotensive women we found a positive association between the C-IMT and sodium intake. The atherosclerotic pl...
Source: Experimental Gerontology - Category: Geriatrics Authors: Tags: Exp Gerontol Source Type: research