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AstraZeneca's drug Fasenra flops in COPD trial

LONDON (Reuters) - AstraZeneca's said its first respiratory biologic medicine Fasenra failed to meet its target in a clinical trial treating patients with moderate to very severe chronic obstructive pulmonary disease (COPD).
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news

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Conclusions: Procaterol assist use modestly but significantly improved pulmonary function determined by spirometry and respiratory mechanics in patients with stable COPD treated with long-acting bronchodilators. Thus, inhaled procaterol has potential for assist use for COPD.
Source: Medical Principles and Practice - Category: Internal Medicine Source Type: research
Conclusion Theophylline clearance was significantly associated with FFM and CYP1A2*1B genotypes in Chinese adult patients.
Source: International Journal of Clinical Pharmacy - Category: Drugs & Pharmacology Source Type: research
IJERPH, Vol. 15, Pages 1021: Analysis of Short-Term Smoking Effects in PBMC of Healthy Subjects—Preliminary Study International Journal of Environmental Research and Public Health doi: 10.3390/ijerph15051021 Authors: Joanna Wieczfinska Tomasz Kowalczyk Przemyslaw Sitarek Ewa Skała Rafal Pawliczak Early structural changes exist in the small airways before the establishment of Chronic Obstructive Pulmonary Disease (COPD). These changes are believed to be induced by oxidation. The aim of this study was to analyze the influence of short-term smoking on the expression of the genes contributing to airway r...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
We examined questions using the National Health and Nutrition Examination Survey III database linked to the National Death Index. The data from 4434 participants were stratified into 4 groups, those with asthma, COPD, ACO, and those without any obstructive lung disease. We examined baseline demographics and used multivariate logistic regression to model the impact of demographics, smoking, and self-reported, physician-diagnosed lung disease on mortality generating odds ratios (ORs) and confidence intervals (CIs). RESULTS: Among 4434 participants, 120 (2.7%), 340 (7.6%), and 126 (2.8%) participants self-reported diagnos...
Source: Southern Medical Journal - Category: General Medicine Tags: South Med J Source Type: research
Acta Ophthalmologica, EarlyView.
Source: Acta Ophthalmologica - Category: Opthalmology Authors: Source Type: research
International Journal of Nursing Practice, EarlyView.
Source: International Journal of Nursing Practice - Category: Nursing Authors: Source Type: research
The objective of this task force was to issue a statement with research recommendations about lung disease models by facilitating in-depth discussions between respiratory scientists, and to provide an overview of the literature on the available models. Focus was put on their specific benefits and limitations. This will result in more efficient use of resources and greater reduction in the numbers of animals employed, thereby enhancing the ethical standards and translational capacity of experimental research. The task force statement addresses general issues of experimental research (ethics, species, sex, age, ex vivo and i...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Original Articles: ERS statement Source Type: research
This study aims to investigate nonlinear parameters such as largest Lyapunov exponent (LLE) and correlation dimension of electrodermal activity signals recorded from healthy subjects and patients with COPD. Electrodermal activity signals recorded from 14 healthy subjects and 24 patients with COPD were analysed. Auditory and tactile stimuli were applied at different time intervals during the recording process. Signals were reconstructed in the phase space compatible with theory and LLE and correlation dimension values were calculated. Statistical analysis was performed by using Shapiro –Wilk normality test, one-way an...
Source: Australasian Physical and Engineering Sciences in Medicine - Category: Biomedical Engineering Source Type: research
An estimated 14.8 million people are currently diagnosed with chronic obstructive pulmonary disease (COPD) in the US. However, the true number is substantially more: National Institutes of Health statistics suggest there may be up to 12 million undiagnosed patients.1 This translates to 10 –21% of older adults seen in medical practices.2 Improved detection of COPD is key to optimal treatment and prevention of deterioration in patients. COPD should be included in the differential diagnoses of patients with chronic respiratory symptoms and recurrent acute respiratory events, particula rly among high-risk groups, e.g.
Source: The American Journal of Medicine - Category: General Medicine Authors: Source Type: research
Chronic obstructive pulmonary disease (COPD) is a leading cause of global morbidity and mortality,1 with the burden of disease predicted to increase to the third leading cause of mortality worldwide by 2030.2 In the United States alone, there were an estimated 14.8 million cases of diagnosed COPD in 2010,3 with another 12 million cases estimated to be undiagnosed.3
Source: The American Journal of Medicine - Category: General Medicine Authors: Source Type: research
More News: AstraZeneca | Chronic Obstructive Pulmonary | Clinical Trials | Health | Respiratory Medicine