AstraZeneca's drug Fasenra flops in COPD trial

LONDON (Reuters) - AstraZeneca's said its first respiratory biologic medicine Fasenra failed to meet its target in a clinical trial treating patients with moderate to very severe chronic obstructive pulmonary disease (COPD).
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news

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Publication date: Available online 21 July 2018Source: Respiratory Physiology &NeurobiologyAuthor(s): Lin Lin, Lili Guan, Weiliang Wu, Rongchang ChenAbstractObjectivesTo assess the correlation between surface respiratory electromyography(sEMG) and esophageal diaphragm electromyography(EMGdi) at different levels of neural respiratory drive (NRD).DesignRandomised parallel design controlled trial.SettingThe First Affiliated Hospital of Guangzhou Medical University.Participants15 healthy subjects and 1 severe to very severe stable COPD patients were studied.Interventions15 healthy subjects performed incremental inspiratory...
Source: Respiratory Physiology and Neurobiology - Category: Respiratory Medicine Source Type: research
Abstract Chronic obstructive pulmonary disease (COPD) is a respiratory disorder characterized by a progressive and irreversible airflow limitation. COPD is associated to a chronic inflammatory response with infiltration of inflammatory cells in the surface epithelium of large airways and abnormalities in structure and functions of cilia. Thyme (Thymus vulgaris L.) is a traditional medicinal plant of the Mediterranean area used to treat respiratory disorders. We previously evidenced that thyme extract reduce IL-1beta and IL-8, by downregulating the activated NF-κB levels, suggesting its potential therapeutica...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - Category: Drugs & Pharmacology Authors: Tags: Biomed Pharmacother Source Type: research
Publication date: Available online 20 July 2018Source: Seminars in Cell &Developmental BiologyAuthor(s): Jennifer Thomson, Mukti Singh, Alexander Eckersley, Stuart A. Cain, Michael J. Sherratt, Clair BaldockAbstractFibrillin microfibrils are extensible polymers that endow connective tissues with long-range elasticity and have widespread distributions in both elastic and non-elastic tissues. They act as a template for elastin deposition during elastic fibre formation and are essential for maintaining the integrity of tissues such as blood vessels, lung, skin and ocular ligaments. A reduction in fibrillin is seen in tiss...
Source: Seminars in Cell and Developmental Biology - Category: Cytology Source Type: research
Authors: McGrath JJC, Stampfli MR PMID: 30023106 [PubMed]
Source: Journal of Thoracic Disease - Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research
Patients with COPD are frequently diagnosed with cardiovascular disease. Peripheral endothelial dysfunction is an underlying mechanism and can be used as an early marker of cardiovascular impairment. To date, little is known on the association between peripheral endothelial dysfunction, cardiovascular risk factors and measurements of exercise capacity in patients with COPD. Therefore, we aimed to determine the relation between endothelial function and patient characteristics, cardiovascular risk factors and (micro)vascular and functional performance in patient with CODP.
Source: Respiratory Medicine - Category: Respiratory Medicine Authors: Source Type: research
Authors: de Sire R, Rizzatti G, Ingravalle F, Pizzoferrato M, Petito V, Lopetuso L, Graziani C, de Sire A, Mentella MC, Mele MC, Gasbarrini A, Scaldaferri F Abstract In recent years, there has been an increasing interest on muscle wasting, considering the reduction of quality of life and the increase of morbidity and mortality associated. Sarcopenia and cachexia represent two conditions of reduction of muscle mass, sharing several elements involved in their pathogenesis, such as systemic inflammation, impaired muscle protein synthesis, increased muscle apoptosis, mitochondrial dysfunction in skeletal muscle tissue ...
Source: Minerva Gastroenterologica e Dietologica - Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research
The objective of the study was to evaluate the relative prevalence of cardiovascular as well as other comorbidities, in patients with the overlap syndrome, as compared to patients that are diagnosed solely with OSA. PATIENTS AND METHODS: We examined thirty-eight (38) patients (27 men, 11 women) with coexisting COPD and OSA - overlap syndrome (Group 1) vs. 38 patients with OSA-only (Group 2), matched for sex, age, and Body Mass Index (BMI). All patients underwent pulmonary function tests (PFTs), oximetry and overnight polysomnography and were asked about other coexisting chronic diseases and medications. RESULTS: Th...
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
CONCLUSIONS: These findings supported that miR-218-5p may, therefore, play an important role in the pathogenesis of COPD. PMID: 30024625 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Source: BMJ Comments - Category: General Medicine Source Type: forums
An 85-year-old patient with a history of oxygen-dependent chronic obstructive pulmonary disease and coronary artery bypass grafting (LIMA-LAD, free vein-circumflex) presented to the emergency department with chest and back pain. Computed tomography angiography (CTA) confirmed acute type a thoracic aortic dissection limited to the ascending thoracic aorta. Aneurysm size is 10 cm. This patient was evaluated by cardiovascular surgeons who offered the patient palliative care secondary to perioperative risk and sent home.
Source: Journal of Vascular Surgery - Category: Surgery Authors: Tags: Abstract from the 2018 Eastern Vascular Society Annual Meeting Source Type: research
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