Transcriptional profiling of the ductus arteriosus: Comparison of rodent microarrays and human RNA sequencing

DA closure is crucial for the transition from fetal to neonatal life. This closure is supported by changes to the DA ′s signaling and structural properties that distinguish it from neighboring vessels. Examining transcriptional differences between these vessels is key to identifying genes or pathways responsible for DA closure. Several microarray studies have explored the DA transcriptome in animal models but va ried experimental designs have led to conflicting results. Thorough transcriptomic analysis of the human DA has yet to be performed.
Source: Seminars in Perinatology - Category: Perinatology & Neonatology Authors: Source Type: research