Association between Prophylactic Indomethacin and Death or Bronchopulmonary Dysplasia: A Systematic Review and Meta-Analysis of Observational Studies

The use of prophylactic indomethacin in very preterm infants is controversial. The last randomized controlled trial (RCTs) to study this therapy enrolled infants over 20 years ago. More recently, observational studies have investigated the association between exposure to prophylactic indomethacin and neonatal morbidities and mortality. We performed a systematic review and meta-analysis of these studies for the outcomes of death and bronchopulmonary dysplasia (BPD). Two observational studies involving a total of 11,289 very preterm infants were suitable for meta-analysis.
Source: Seminars in Perinatology - Category: Perinatology & Neonatology Authors: Tags: 42/4 Source Type: research