UCLA-led research finds vaccines against anthrax, plague and tularemia are effective in mice

Anthrax, plague and tularemia are three potent agents terrorists would be likely to use in an attack, according to the Centers for Disease Control and Prevention. Each is highly and quickly lethal to humans. But there are no licensed vaccines for tularemia and plague, and although there is an anthrax vaccine, it requires a burdensome immunization schedule and has severe side effects.Now, a UCLA-led group of researchers may have found a solution that, if found to be safe and effective in humans, could protect people from all three bacteria. The team used molecular engineering to develop vaccines against each that use a common delivery method, or “single vector,” to carry protective antigens to the immune system.The findings were published May 3 in Scientific Reports.“Relying on currently available antibiotics to counter an intentional outbreak of anthrax, plague or tularemia is not a pragmatic public health plan — vaccines offer the only practical protection,” said Dr. Marcus Horwitz, the study’s senior author and a distinguished professor of medicine a nd of microbiology, immunology and molecular genetics at theDavid Geffen School of Medicine at UCLA.“Vaccines utilizing a single vector that could be administered concurrently and protect against all three pathogens would be more acceptable to people than multiple unrelated vaccines requiring different immunization schedules, and be less costly because they would be simpler to manufactu...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news

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In this study, a transposon mutagenesis approach was applied to reveal the factors involved in resistance to oxidative stress, and the biofilm formation among mutants and WT strains were further detected using crystal violet staining (CVS), scanning electron microscopy (SEM), and confocal laser scanning microscopy (CLSM) to reveal potential relationship between oxidative stress and biofilm formation. Materials and Methods The Development of Mutants Library The procedure of transposon mutagenesis approach was performed as described by Zhang et al. (2018). Screening of Mutants Tolerance to Oxidative Stress For screening...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Conclusion Since B. cereus group are highly similar in biochemical as well as genetic profiles, a new biomarker was developed for identifying and distinguishing B. thuringiensis from the closely related group. The performance of XRE was compared with cry2 gene and artificially contaminated samples were also tested. Compared with cry2, XRE gene was observed to be efficiently accurate in the identification of B. thuringiensis. Further, the developed real-time PCR using XRE successfully identified B. thuringiensis and it could be used to quantify cell numbers with the generated standard curve. Author Contributions The expe...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Murat Bağcıoğlu1,2†, Martina Fricker1†‡, Sophia Johler2 and Monika Ehling-Schulz1* 1Functional Microbiology, Institute of Microbiology, Department of Pathobiology, University of Veterinary Medicine Vienna, Vienna, Austria 2Institute for Food Safety and Hygiene, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland The Bacillus cereus group comprises genetical closely related species with variable toxigenic characteristics. However, detection and differentiation of the B. cereus group species in routine diagnostics can be difficult, expensive and laborious since current species desi...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
This study was supported by the Israel Institute for Biological Research, Ness Ziona, Israel. Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Acknowledgments We thank Dr. Vered Caspi (Ben-Gurion University) for assisting with the bioinformatics and statistical analyses of the Agilent DNA microarray results. Supplementary Material The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fmicb.2019.00754/full#s...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
A suspected anthrax outbreak is raising alarm at Lake Nakuru National Park in Kenya after the sudden deaths of 10 buffalo since last month, and officials are working to make sure the outbreak doesn't put humans at risk.
Source: CNN.com - Health - Category: Consumer Health News Source Type: news
Research ArticlesJ. L. HU, L. L. CUI, C. J. BAO, Z. M. TAN, S. RUTHERFORD, L. YING, M. L. ZHANG, F. C. ZHU,Epidemiology&Infection,Volume 144 Issue 12, pp 2672-2678Abstract
Source: Epidemiology and Infection - Category: Epidemiology Source Type: research
Conclusion: A brief checklist covering symptoms and signs can distinguish anthrax from other conditions with minimal need for diagnostic testing after known or suspected population exposure. Primary Funding Source: U.S. Department of Health and Human Services. PMID: 30884525 [PubMed - as supplied by publisher]
Source: Annals of Internal Medicine - Category: Internal Medicine Authors: Tags: Ann Intern Med Source Type: research
[Malawi News Agency] Blantyre -Government has warned livestock farmers in the country of an Anthrax outbreak scare recently reported in Momba district located in the Songwe region of Tanzania.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
[The Herald] An outbreak of anthrax has affected eight people in Zvimba district after they ate meat from a cow that had died of the disease.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
This study also provides preliminary survey results regarding the population diversity ofB.anthracis in China, which will help promote the prevention and control of this important disease.
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
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