UCLA-led research finds vaccines against anthrax, plague and tularemia are effective in mice

Anthrax, plague and tularemia are three potent agents terrorists would be likely to use in an attack, according to the Centers for Disease Control and Prevention. Each is highly and quickly lethal to humans. But there are no licensed vaccines for tularemia and plague, and although there is an anthrax vaccine, it requires a burdensome immunization schedule and has severe side effects.Now, a UCLA-led group of researchers may have found a solution that, if found to be safe and effective in humans, could protect people from all three bacteria. The team used molecular engineering to develop vaccines against each that use a common delivery method, or “single vector,” to carry protective antigens to the immune system.The findings were published May 3 in Scientific Reports.“Relying on currently available antibiotics to counter an intentional outbreak of anthrax, plague or tularemia is not a pragmatic public health plan — vaccines offer the only practical protection,” said Dr. Marcus Horwitz, the study’s senior author and a distinguished professor of medicine a nd of microbiology, immunology and molecular genetics at theDavid Geffen School of Medicine at UCLA.“Vaccines utilizing a single vector that could be administered concurrently and protect against all three pathogens would be more acceptable to people than multiple unrelated vaccines requiring different immunization schedules, and be less costly because they would be simpler to manufactu...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news

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Abstract Epidemiologic data indicate a global distribution of anthrax outbreaks associated with certain ecosystems that promote survival and viability of Bacillus anthracis spores. Here, we characterized three anthrax outbreaks involving humans, livestock, and wildlife that occurred in the same locality in Kenya between 2014 and 2017. Clinical and epidemiologic data on the outbreaks were collected using active case finding and review of human, livestock, and wildlife health records. Information on temporal and spatial distribution of prior outbreaks in the area was collected using participatory epidemiology. The 2...
Source: The American Journal of Tropical Medicine and Hygiene - Category: Tropical Medicine Authors: Tags: Am J Trop Med Hyg Source Type: research
Bacillus endophyticus is a soil plant-endophytic bacterium, while B. anthracis is the causative agent of anthrax. The virulence factors of B. anthracis are the plasmid encoded tripartite toxins (pXO1) and poly- γ-...
Source: BMC Microbiology - Category: Microbiology Authors: Tags: Research article Source Type: research
Anthrax is a serious infectious disease caused by bacteria known asBacillus anthracis. Anthrax-contaminated spores can be found naturally in soil and they commonly affect domestic and wild animals around the world. Although rare in the United States, people can get sick with anthrax if they come in contact with infected animals or contaminated animal products.CDC researchers have developed a lateral flow immunoassay using monoclonal antibodies againstBacillus anthracis toxin and its components, lethal factor (LF) and protective antigen (PA). These antibodies have been screened and optimized into anti-LF and anti-PA pairs, ...
Source: NIH OTT Licensing Opportunities - Category: Research Authors: Source Type: research
[Monitor] Arua -Nineteen people have so far been infected following the outbreak of the deadly anthrax in Arua District.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
, Vazquez F Abstract In the period from 1915 to 1924 anthrax outbreaks were described by Bacillus anthracis due to the contamination of razor brushes that reached Europe and the United States from areas such as Japan, China or Russia. The brushes were made with badger hair, and then, to reduce the cost with horse hair and other animals. World War I supoosed that the traffics of these brushes, that passed through Europe, changed and the processes of sterilization of the same were deficient giving rise to these outbreaks, that in a percentage of 20% produced the death of the users. The impact of the fashion of weari...
Source: Revista Espanola de Quimioterapia - Category: Drugs & Pharmacology Authors: Tags: Rev Esp Quimioter Source Type: research
[East African] A South Sudanese refugee has died from anthrax at a refugee camp in northwestern Uganda, a local official said on Friday.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
PMID: 29608180 [PubMed - in process]
Source: The Canadian Veterinary Journal - Category: Veterinary Research Authors: Tags: Can Vet J Source Type: research
LITFL • Life in the Fast Lane Medical Blog LITFL • Life in the Fast Lane Medical Blog - Emergency medicine and critical care medical education blog Just when you thought your brain could unwind on a Friday, you realise that it would rather be challenged with some good old fashioned medical trivia FFFF…introducing Funtabulously Frivolous Friday Five 231. Readers can subscribe to FFFF RSS or subscribe to the FFFF weekly EMAIL Question 1: You find yourself on holiday in Africa helping out with a dermatology clinic (yes, your forte as an emergency physician). In the queue is a young boy who describes&nb...
Source: Life in the Fast Lane - Category: Emergency Medicine Authors: Tags: Frivolous Friday Five anthrax cholera Dilip Mahalanabis Dr Bayford dysentery dysphagia lusoria ORS saber shins Thomas Hodgkin wool-sorters disease yaws Source Type: blogs
No abstract available
Source: The Pediatric Infectious Disease Journal - Category: Infectious Diseases Tags: Current Abstracts Source Type: research
Discussion: Our study was designed to provide a concise and east-to-apply set of criteria that could be used by NATO nations to evaluate emerging infectious disease threats with respect to their weaponization potential. Our results were unexpected. We believe that a lack of appropriate weighting factors may explain these results and suggest that future studies weigh each of the 12 proposed criteria based on the intended use of the assessment data and other situational factors. We believe that the greatest value of our study lies in a codification of the attributes of a biological weapon. PMID: 29401327 [PubMed - in process]
Source: Military Medicine - Category: International Medicine & Public Health Tags: Mil Med Source Type: research
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