The HLA-G Genetic Contribution to Bipolar Disorder: A Trans-Ethnic Replication.

The HLA-G Genetic Contribution to Bipolar Disorder: A Trans-Ethnic Replication. Immunol Invest. 2018 May 08;:1-12 Authors: Sundaresh A, Wu CL, Chinnadurai RK, Rajkumar RP, Mariaselvam CM, LeMaoult J, Krishnamoorthy R, Leboyer M, Negi VS, Tamouza R Abstract Bipolar disorder (BD) is frequently associated with immune dysfunctions. Studying the genetic diversity of the immuno-modulatory human leukocyte antigen (HLA)-G locus in a French BD cohort, we previously reported an association between a functionally relevant 14 bp Ins/Del polymorphism and BD risk. The present study investigated the genetic and expression diversities of HLA-G in a geographically distinct South Indian population-group BD patients, as well as the influence of exposure to the neurotropic Toxoplasma gondii pathogen. Three functionally relevant HLA-G polymorphisms, i.e. HLA-G 14 bp Ins/Del (rs66554220), +3142G>C (rs1063320) and +3187A>G (rs9380142) were genotyped by polymerase chain reaction (PCR) and real-time PCR. Sub-samples of BD patients and healthy controls (HC) were investigated for plasma levels of soluble HLA-G (sHLA-G) isoforms, as well as circulating stigma of T. gondii infection. Findings indicate: (i) the frequency of the HLA-G 14 bp Del/Del genotype was higher in BD cases, as compared to HC; (ii) the HLA-G + 3142 C allele and CC genotype were more prevalent in BD patients than in HC; (iii) sHLA-G levels were significantly higher in BD cases, esp...
Source: Immunological Investigations - Category: Allergy & Immunology Tags: Immunol Invest Source Type: research