Identification of broad-spectrum dengue/Zika virus replication inhibitors by functionalization of quinoline and 2,6-diaminopurine scaffolds.

Identification of broad-spectrum dengue/Zika virus replication inhibitors by functionalization of quinoline and 2,6-diaminopurine scaffolds. ChemMedChem. 2018 May 09;: Authors: Kaptein SJF, Vincetti P, Crespan E, Armijos-Rivera JI, Costantino G, Maga G, Neyts J, Radi M Abstract Social and demographic changes over the past 50 years resulted in important outbreaks of arboviruses such as dengue virus (DENV) and Zika virus (ZIKV) all over the world. Despite such potential threat, no approved drugs or fully protective vaccines are available to counteract DENV and ZIKV spreading. The development of "broad spectrum" antivirals (BSAs) targeting common components of multiple viruses, can be a more effective strategy to limit the rapid rise of emerging viral pathogens than the classic "one-bug/one-drug" approach. Starting from previously identified multitarget DENV inhibitors, we report herein the identification of novel 2,6-diaminopurine derivatives able to block the replication of both Zika virus and all serotypes of dengue virus (DENV 1-4) in infected cells. PMID: 29740962 [PubMed - as supplied by publisher]
Source: ChemMedChem - Category: Chemistry Authors: Tags: ChemMedChem Source Type: research