Histopathology after microelectrode recording and twelve years of deep brain stimulation

Despite the widespread use of deep brain stimulation (DBS), studies on the histological alterations induced by the DBS electrode remain relatively scarce. Typical findings include fibrous sheaths of 5-25 μm surrounding the electrode track, a chronic inflammation with reactive astrocytes, multinucleated giant cells, macrophages, mononuclear leucocytes and T-lymphocytes, fibrillary gliosis and Rosenthal fibers [1,2].

Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - May 9, 2018 Category: Neurology Authors: Philippe De Vloo, Dietmar Thal, Kris van Kuyck, Bart Nuttin Source Type: research