Cocaine induced structural plasticity in input regions to distinct cell types in nucleus accumbens

The nucleus accumbens (NAc) is a brain region implicated in pathological motivated behaviors such as drug addiction and is comprised predominantly of two discrete populations of neurons, dopamine receptor-1 and dopamine receptor-2 expressing medium spiny neurons (D1-MSNs and D2-MSNs, respectively). It is unclear whether these populations receive inputs from different brain areas and whether input regions to these cell-types undergo distinct structural adaptations in response to administration of addictive drugs such as cocaine.
Source: Biological Psychiatry - Category: Psychiatry Authors: Tags: Archival Report Source Type: research