Hydralazine-associated adverse events: a report of two cases of hydralazine-induced ANCA vasculitis.

Hydralazine-associated adverse events: a report of two cases of hydralazine-induced ANCA vasculitis. J Bras Nefrol. 2018 May 07;: Authors: Zuckerman R, Patel M, Costanzo EJ, Dounis H, Haj RA, Seyedali S, Asif A Abstract Hydralazine is a direct-acting vasodilator, which has been used in treatment for hypertension (HTN) since the 1950s. While it is well known to cause drug-induced lupus (DIL), recent reports are indicating the emergence of the drug-induced anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitis (DIV). Herein, we describe two patients (aged 57 and 87 years) who presented with severe acute kidney injury (AKI), proteinuria, and hematuria. Both were receiving hydralazine for the treatment of hypertension. ANCA serology was positive in both patients along with anti-histone antibodies (commonly seen in drug-induced vasculitis). Renal biopsy revealed classic crescentic (pauci-immune) glomerulonephritis in these patients and hydralazine was discontinued. During the hospital course, the 57-year-old patient required dialysis therapy and was treated with steroids and rituximab for the ANCA disease. Renal function improved and the patient was discharged (off dialysis) with a serum creatinine of 3.6 mg/dL (baseline = 0.9 mg/dL). At a follow-up of 2 years, the patient remained off dialysis with advanced chronic kidney disease (CKD) (stage IIIb). The 87-year-old patient had severe AKI with serum creatinine at 10.41 mg/dL (baseline = 2.27 mg/dL)....
Source: Jornal Brasileiro de Nefrologia - Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

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Source: Annals of Laboratory Medicine - Category: Laboratory Medicine Tags: Ann Lab Med Source Type: research
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Source: Medical Journal of Australia - Category: General Medicine Tags: Med J Aust Source Type: research
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Source: Life Sciences - Category: Biology Source Type: research
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Source: Revista Espanola de Cardiologia - Category: Cardiology Source Type: research
HIGH blood pressure, or hypertension, is diagnosed by a reading over 140/90 mmHg taken on the arm. This measurement can be caused by a high salt diet and little exercise. But, when is blood pressure lowest?
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Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Habits Happiness Source Type: blogs
Publication date: Available online 21 July 2018Source: American Journal of Kidney DiseasesAuthor(s): Jennifer S. McDonald, Robert J. McDonald, Cheryl L. Tran, Amy B. Kolbe, Eric E. Williamson, David F. KallmesRational &ObjectiveThe risks of iodinated contrast material administered to pediatric patients are not well defined. The purpose of this study was to examine the rates of postcontrast acute kidney injury (AKI), dialysis therapy, and death following administration of intravenous contrast material to pediatric patients.Study DesignRetrospective cohort study.Setting &ParticipantsPediatric (aged 
Source: American Journal of Kidney Diseases - Category: Urology & Nephrology Source Type: research
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Source: International Journal of Cardiology - Category: Cardiology Authors: Tags: Editorial Source Type: research
In this study, the number of circulating endothelial progenitor cells (EPC) is lower in naïve pulmonary artery hypertension (PAH) patients, and treatment of PAH-tar geted drugs increased EPC levels in the blood of PAH patients. However, there is no elevation of circulating EPC in chronic thromboembolic pulmonary hypertension patients.
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Patients with chronic kidney disease are at increased risk of cardiovascular disease (CVD). Even after kidney transplant, the rate of CVD events and death remain elevated. Early detection of patients at risk would be helpful for guiding aggressive preventive therapy. The purpose of this study was to evaluate global longitudinal strain (GLS) as a predictor of CVD events and death after kidney transplant.
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