This Osteoporosis Drug Has a Surprising Side-Effect. Scientists Say It Could Cure Baldness

Researchers may have discovered a new cure for baldness using a drug initially intended to treat osteoporosis. Scientists from the University of Manchester say the drug,WAY-316606, stimulated hair growth in the lab by targeting a protein that halts hair growth and contributes to baldness, BBC reports. They were originally testing Cyclosporine A, an immunosuppressive drug that has been used since the 1980s to stop rejections in organ transplants and mitigate symptoms of autoimmune diseases. While it was found to suppress hair loss, Cyclosporine A had side-effects that made it unsuitable. So the team went on looking for a drug with similar attributes; they found it in WAY-316606. Published in the journal PLOS Biology, the research tested more than 40 samples of hair follicles from hair-transplant patients. A clinical trial will be necessary to ensure the treatment is safe, according to project leader Dr Nathan Hawkshaw. Currently there are only two drugs available to remedy balding, according to the BBC. Minoxidil works for men and women, but finasteride can only be used by men. The new treatment could “make a real difference to people who suffer from hair loss,” says Dr. Hawkshaw, BBC reports.
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized onetime overnight Research Source Type: news

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Conclusions. Multiple factors were associated with a significantly increased risk of VFX compared with NVFX. Understanding the risk factors unique to fragility VFX is a critical component for targeting “at-risk” patients and preventing future osteoporosis-related fractures and their consequences. Level of Evidence: 4
Source: Spine - Category: Orthopaedics Tags: EPIDEMIOLOGY Source Type: research
AbstractPurposePatients with diagnosis of diffuse large B-cell lymphoma, who relapse after stem cell transplant (SCT) or are no candidates to SCT, have a poor prognosis and no current treatment is available. Thus, we conduct a rotatory chemotherapy schedule that employed low doses of chemotherapy agents to assess efficacy and toxicity in this setting of patients; the end point was the improved outcome.MethodsRetrospectively we revised an analysis of 461 patients who were treated with a low-doses regimen of cytotoxic agents, who were treated in a single institution, all patients has been treated with at least two salvage re...
Source: Clinical and Translational Oncology - Category: Cancer & Oncology Source Type: research
Publication date: Available online 16 March 2020Source: Best Practice &Research Clinical AnaesthesiologyAuthor(s): Carolyn Thai, Cynthia Oben, Gebhard Wagener
Source: Best Practice and Research Clinical Anaesthesiology - Category: Anesthesiology Source Type: research
Conditions:   Philadelphia-Negative ALL;   High-Risk Cancer Intervention:   Drug: Blinatumomab Sponsor:   Israeli Medical Association Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   T Cell Lymphoma Intervention:   Drug: Brentuximab Vedotin Sponsors:   Siddhartha Ganguly;   Seattle Genetics, Inc. Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Chronic Allograft Injury Interventions:   Drug: UCB7858;   Drug: Placebo Sponsor:   UCB Biopharma SRL Active, not recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
In conclusion, a polypharmacology approach of combining established, prolongevity drug inhibitors of specific nodes may be the most effective way to target the nutrient-sensing network to improve late-life health. Deletion of p38α in Neurons Slows Neural Stem Cell Decline and Loss of Cognitive Function in Mice https://www.fightaging.org/archives/2019/10/deletion-of-p38%ce%b1-in-neurons-slows-neural-stem-cell-decline-and-loss-of-cognitive-function-in-mice/ Researchers here provide evidence for p38α to be involved in the regulation of diminished neural stem cell activity with age. It is thought...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
In the several decades since the need for dietary zinc was discovered, it has proven to be far more important to overall health than initially thought. And deficiency is proving to be common. You may recall that the phytates of wheat and grains block nearly all absorption of dietary zinc, along with blocking iron, calcium, and magnesium (all positively-charged cations). Just as iron deficiency anemia with hemoglobin values of 7 or 8 g/dl resistant to iron supplementation commonly develops in grain-consuming populations, so a parallel zinc deficiency also develops (although not well reflected by blood levels of zinc, which ...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Undoctored Wheat Belly Lifestyle autoimmune gastrointestinal gluten gluten-free grain grain-free grains hormonal Inflammation phytates rash zinc Source Type: blogs
By: Dr. Alan Christianson When someone you know is living with hypothyroidism, it can be tempting to think that if only the doctor would prescribe an extra helping of thyroid hormone, your friend or loved one would feel so much better and would enjoy life more. And in some cases, an extra helping might be in order. In other cases, not so much. Too much thyroid hormone can actually be dangerous, which is why doctors are loathe to bump the levothyroxin dosage up an extra 25 micrograms or so for one of their patients who's still experiencing hypothyroid symptoms. Tests always come first, and there's a good reason for that....
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news
Publication date: Available online 10 May 2016 Source:The Lancet Diabetes & Endocrinology Author(s): Rosario Pivonello, Andrea M Isidori, Maria Cristina De Martino, John Newell-Price, Beverly M K Biller, Annamaria Colao Cushing's syndrome is a serious endocrine disease caused by chronic, autonomous, and excessive secretion of cortisol. The syndrome is associated with increased mortality and impaired quality of life because of the occurrence of comorbidities. These clinical complications include metabolic syndrome, consisting of systemic arterial hypertension, visceral obesity, impairment of glucose metabolism, ...
Source: The Lancet Diabetes and Endocrinology - Category: Endocrinology Source Type: research
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