Intermittent streptozotocin administration induces behavioral and pathological features relevant to Alzheimer's disease and vascular dementia.

CONCLUSIONS: STZ-treated animals exhibit cognitive deficits and histopathological changes seen in dementia. This model of dementia warrants continued investigation to better understand the role that DM plays in dementia-related alterations.
PMID: 29738850 [PubMed - as supplied by publisher]

Source: Neuropharmacology - May 5, 2018 Category: Drugs & Pharmacology Authors: Murtishaw AS, Heaney CF, Bolton MM, Belmonte KCD, Langhardt MA, Kinney JW Tags: Neuropharmacology Source Type: research