Corticosteroid Use Decreases Voriconazole Concentration

Corticosteroid Use Decreases Voriconazole ConcentrationWed, 05/09/2018 - 13:17News blog
Source: The Aspergillus Website - updates - Category: Respiratory Medicine Authors: Source Type: news

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We present a case of a 61-year-old man with hepatocellular carcinoma and a previous history of metabolic and alcoholic cirrhosis who underwent orthotopic liver transplant. The immunosuppression regimen consisted of corticosteroids, calcineurin inhibitor, and mammalian target of rapamycin complex 1 inhibitor. Nine days after surgery, the patient developed leukopenia and skin rash. After confirmation of graft-versus-host disease by chimerism and skin biopsy, etanercept, a novel anti-tumor necrosis factor-alpha drug used for patients with hematologic and rheumatologic disease, was administrated. Unfortunately, no clinical imp...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - Category: Transplant Surgery Authors: Tags: Exp Clin Transplant Source Type: research
CONCLUSIONS: There is lack of evidence for the efficacy and safety of anti-IgE (omalizumab) therapy in people with cystic fibrosis and allergic bronchopulmonary aspergillosis. There is a need for large prospective randomized controlled studies of anti-IgE therapy in people with cystic fibrosis and allergic bronchopulmonary aspergillosis with both clinical and laboratory outcome measures such as steroid requirement, allergic bronchopulmonary aspergillosis exacerbations and lung function. PMID: 29551015 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - Category: General Medicine Authors: Tags: Cochrane Database Syst Rev Source Type: research
Abstract Severe asthma with fungal sensitization predominates in the population suffering from allergic asthma, to which there is no cure. While corticosteroids are the mainstay in current treatment, other means of controlling inflammation may be beneficial. Herein, we hypothesized that mannan from Saccharomyces cerevisiae would dampen the characteristics of fungal allergic asthma by altering the pulmonary immune responses. Using wild-type and transgenic mice expressing the human mannose receptor on smooth muscle cells, we explored the outcome of mannan administration during allergen exposure on the pathogenesis o...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
Publication date: Available online 7 March 2018 Source:Medical Mycology Case Reports Author(s): Jessica D. Workum, Suzanne W. de Jong, Mark S. Gresnigt, Katharina L. Becker, Peter Pickkers, Frank L. van de Veerdonk, Yvonne F. Heijdra, Eva Kolwijck Invasive pulmonary aspergillosis is increasingly described in non-neutropenic patients, such as patients with COPD receiving corticosteroids and the critically ill. Here, we present a case of a lethal pulmonary Aspergillus niger infection in a COPD patient. Immunological tests showed an impaired innate and adaptive immune response to Aspergillus. A history of COPD, unresponsiven...
Source: Medical Mycology Case Reports - Category: Biology Source Type: research
We report a case of successful treatment of probable invasive pulmonary aspergillosis due to A. lentulus and polymicrobial infection with Pseudomonas aeruginosa in a patient with relapsing granulomatosis with polyangiitis and recent high-dose steroid therapy.
Source: Infectious Diseases in Clinical Practice - Category: Infectious Diseases Tags: Case Reports Source Type: research
Publication date: Available online 31 January 2018 Source:Respiratory Medicine Case Reports Author(s): Atsushi Suzuki, Tomoki Kimura, Kensuke Kataoka, Toshiaki Matsuda, Toshiki Yokoyama, Yuta Mori, Yasuhiro Kondoh Acute exacerbation (AE) is a severe and life-threatening complication of idiopathic pulmonary fibrosis (IPF). In 2016, the definition and diagnostic criteria for AE-IPF were updated by an international working group. The new definition includes any acute, clinically significant respiratory deterioration (both idiopathic and triggered events) characterized by evidence of new widespread alveolar abnormality in pat...
Source: Respiratory Medicine Case Reports - Category: Respiratory Medicine Source Type: research
Conclusions: Frequency of infection in APAP cases were similar to the previous report. Infection might improve or deteriorate the clinical course of APAP.Financial support: This study was partially granted from AMED; DLD/14526278 to Y. Inoue and T. Arai and PAP/14526182 to Y. Inoue.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Diffuse Parenchymal Lung Disease Source Type: research
Conclusion: Incidence of infectious diseases was relatively high in patients with nivolumab treatment. ICI has a potential risk for infectious disease regardless of steroid use.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Lung Cancer Source Type: research
Conclusion: ABPA is commonly misdiagnosed as pulmonary TB in high burden TB country. Early diagnosis and appropriate treatment can prevent the structural damage to the lungs.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Allergy and immunology Source Type: research
Aspergillosis is responsible for a large spectrum of entities, from colonization to invasive pulmonary aspergillosis. Incidences of both lung cancer and pulmonary aspergillosis are growing. Because lung cancer is frequently associated to COPD (chronic obstructive pulmonary disease), to architectural abnormalities of bronchus and to a high exposure to corticosteroids, it may facilitate aspergillosis. However, these fungal complications in patients with lung carcinoma are poorly known. The main aims of our study were to analyze the frequency of aspergillosis in a cohort of lung cancer and to identify risk factors.A cohort of...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Respiratory Infections Source Type: research
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