Study of Colombia North Wiwa El Encanto Amerindians HLA- Genes: Pacific Islanders Relatedness.

Study of Colombia North Wiwa El Encanto Amerindians HLA- Genes: Pacific Islanders Relatedness. Hum Immunol. 2018 May 02;: Authors: Arnaiz-Villena A, Palacio-Grüber J, Muñiz E, Hernández E, Bayona B, Campos C, Nuñez J, AdrianLopez-Nares, Martin-Villa M, Silvera C Abstract We have studied Wiwa/Sanja Amerindians HLA-A,-B,-C.-DRB1 and DQB1 allele frequencies and extended haplotypes in 52 unrelated individuals from "El Encanto" town at Guanachacariverside.Highfrequency alleles were in general present in other Amerindian populetions.Also,three extended haplotypes and eight ones were respectively both "new found" and already described in Amerindians from North,Central and South America,including Lakota-Sioux,Mayas,Teeneks,Quechua and Aymaras.Analyses of HLA-A∗24:02 and -C∗01:02 Wiwa high frequency alleles suggested a specific relatedness with another Amerindian and Pacific Islander ethnic groups (these two particular alleles bearing in high frequencies);they include New Zealand Maoris,Taiwanese,Japanese,Papua New Guinea,and Samoans among others.This may indicate that selective forces are mantaining these two alleles high frequency within this wide American/Pacific area. PMID: 29729321 [PubMed - as supplied by publisher]
Source: Human Immunology - Category: Allergy & Immunology Authors: Tags: Hum Immunol Source Type: research